Faculty of Science: Recent submissions
-
Accelerated Protein Synthesis via One-Pot Ligation-Deselenization Chemistry
Published 2017-05-11Peptide ligation chemistry has revolutionized protein science by facilitating access to synthetic proteins. Here, we describe the development of additive-free ligation-deselenization chemistry at β-selenoaspartate and ...Open AccessArticle -
Arabinosylation Modulates the Growth-Regulating Activity of the Peptide Hormone CLE40a from Soybean
Published 2017-09-21Small post-translationally modified peptide hormones mediate crucial developmental and regulatory processes in plants. CLAVATA/ENDOSPERM-SURROUNDING REGION (CLE) genes are found throughout the plant kingdom and encode for ...Open AccessArticle -
Thiazolidine-Protected β-Thiol Asparagine: Applications in One-Pot Ligation–Desulfurization Chemistry
Published 2015-09-23The synthesis of a β-thiol asparagine derivative bearing a novel (2,4,6-trimethoxyphenyl)thiazolidine protecting group is described. The efficient incorporation of the amino acid into the N-termini of peptides is demonstrated ...Open AccessArticle -
Peptide Ligation–Desulfurization Chemistry at Arginine
Published 2013-02-20The utility of a new β‐thiol arginine building block in ligation–desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is ...Open AccessArticle -
Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library To Interrogate HIV Binding and Entry
Published 2014-06-25Tyrosine (Tyr) sulfation is a common post-translational modification that is implicated in a variety of important biological processes, including the fusion and entry of human immunodeficiency virus type-1 (HIV-1). A number ...Open AccessArticle