Peptide Ligation–Desulfurization Chemistry at Arginine
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Open Access
Type
ArticleAbstract
The utility of a new β‐thiol arginine building block in ligation–desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one‐pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.The utility of a new β‐thiol arginine building block in ligation–desulfurization chemistry has been demonstrated through reactions and kinetic studies with a range of peptide thioesters. Application of the method is highlighted by a one‐pot, kinetically controlled, rapid ligation to generate a 7 kDa MUC1 glycopeptide.
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Date
2013-02-20Publisher
WileyFunding information
ARC DP130101984Licence
OtherFaculty/School
Faculty of ScienceShare