Faculty of Science: Recent submissions
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Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies
Published 2018-03-20We recently reported the discovery of non-toxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we report exploration of the structure-activity relationship for ...Open AccessArticle -
Cyclobutanone analogues of beta‐lactam antibiotics: beta‐lactamase inhibitors with untapped potential?
Published 2016-12-19Beta‐Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial ...Open AccessArticle -
Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis
Published 2016-05-23Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against ...Open AccessArticle -
Homogeneous Sulfopeptides and Sulfoproteins: Synthetic Approaches and Applications to Characterize the Roles of Tyrosine Sulfation on Biochemical Function
Published 2015-07-21Post-translational modification of proteins plays critical roles in regulating structure, stability, localization, and function. Sulfation of the phenolic side chain of tyrosine residues to form sulfotyrosine (sTyr) is a ...Open AccessArticle -
Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine
Published 2015-09-01Despite the unique chemical properties of selenocysteine (Sec), ligation at Sec is an under‐utilized methodology for protein synthesis. We describe herein an unprecedented protocol for the conversion of Sec to serine (Ser) ...Open AccessArticle