NHMRC Clinical Trials Centre
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Established in 1988, the NHMRC Clinical Trials Centre (CTC) now has a diverse group of 150 researchers. We have earned an outstanding reputation for contributing to major advances in clinical care via our high-quality collaborative clinical trials research.
Clinical trials research determines how existing drugs and treatments can be used most effectively and explores promising new therapies. Trials answer questions such as:
Is it better for patients with various cancers to have chemotherapy, radiotherapy, or both?
How should patients with heart disease be best treated to reduce the risk of heart attacks or strokes?
What are the benefits and risks of providing higher or lower levels of extra oxygen to very premature newborn babies?
The answers to these types of trials questions have led to important advances in patient care, which have resulted in better health outcomes for patients globally.
For example, thousands of lives are saved each year as a result of new cholesterol treatments, and patients are living longer, better-quality lives as a result of improved therapies for breast, lung, bowel and other cancers.
Towards the future
We will continue our efforts to make clinical trials an integral part of health care. We also plan to maintain and build our global collaborative ties with other research networks, universities, government, and industry, to answer important clinical questions in new therapy areas.Sub-collections in this collection
Recent Submissions
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A Phase II study to evaluate the safety and potential palliative benefit of intraperitoneal bevacizumab in patients with symptomatic ascites due to advanced chemotherapy resistant gynaecological cancers: REZOLVE dataset
Published 2024-07-16This dataset includes 24 female participants (38 - 86 years old) receiving intraperitoneal bevacizumab recruited into the REZOLVE study from six hospitals in New South Wales, Queensland and Victoria, Australia. Baseline ...Dataset -
Effectiveness of a new model of primary care management on knee pain and function in patients with knee osteoarthritis: the PARTNER project dataset
Published 2024-06-18This dataset includes 38 general practices and 217 patient participants ( ≥45 years old, 60% female) participating in a cluster randomised controlled trial to test a new model of telehealth service delivery for knee ...Dataset -
Deferred cord clamping, cord milking, and immediate cord clamping at preterm birth: a systematic review and individual participant data meta-analysis
Published 2023Background Umbilical cord clamping strategies at preterm birth have the potential to affect important health outcomes. The aim of this study was to compare the effectiveness of deferred cord clamping, umbilical cord ...Article -
Short, medium, and long deferral of umbilical cord clamping compared with umbilical cord milking and immediate clamping at preterm birth: a systematic review and network meta-analysis with individual participant data
Published 2023Background Deferred (also known as delayed) cord clamping can improve survival of infants born preterm (before 37 weeks of gestation), but the optimal duration of deferral remains unclear. We conducted a systematic review ...Article -
The Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) dataset
Published 2024-02-23This dataset includes 9,014 participants receiving either pravastatin, 40 mg/day or placebo, with a total cholesterol level at baseline of 4.0 to 7.0 mmol/L (155 to 270 mg/dl) and with a history of acute myocardial infarction ...Dataset