Browsing NHMRC Clinical Trials Centre by title
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1477The landscape of COVID-19 trials in Australia
Published 2021Abstract Background The coronavirus disease 2019 (COVID-19) pandemic has seen a large number of clinical trials launched at unprecedented speed. We aimed to explore the landscape of COVID-19 trials in Australia, and to ...Article -
Adjuvant immunotherapy recommendations for stage III melanoma: physician and nurse interviews
Published 2021Background Adjuvant immunotherapy is revolutionising care for patients with resected stage III and IV melanoma. However, immunotherapy may be associated with toxicity, making treatment decisions complicated. This study ...Open AccessArticle -
Adjuvant therapy with high dose vitamin D following primary treatment of melanoma at high risk of recurrence: A placebo controlled randomised phase II trial (ANZMTG 02.09 Mel-D)
Published 2014Patients with primary cutaneous melanomas that are ulcerated and >2 mm in thickness, >4 mm in thickness and those with nodal micrometastases at diagnosis, have few options for adjuvant treatment. Recent studies have suggested ...Open AccessArticle -
Advance care planning in chronic kidney disease: a survey of current practice in Australia
Published 2016-02-16Aim: Advance care planning (ACP) in nephrology is widely advocated but not always implemented. The aims of this study were to describe current ACP practice and identify barriers/facilitators and perceived need for health ...Open AccessArticle -
Advance Care Planning With Patients Who Have End-Stage Kidney Disease: A Systematic Realist Review
Published 2018Abstract Context Patients with end-stage kidney disease have a high mortality rate and disease burden. Despite this, many do not speak with health care professionals about end-of-life issues. Advance care planning is ...Open AccessArticle -
The AEDUCATE Collaboration. A Comprehensive antenatal education birth preparation programs to reduce rates of caesarean section in nulliparous women. Protocol for an individual participant data prospective meta-analysis
Published 2020Abstract Introduction Rates of medical interventions in normal labour and birth are increasing. This prospective meta-analysis (PMA) proposes to assess whether the addition of a comprehensive multicomponent birth preparation ...Open AccessArticle -
The AEDUCATE Collaboration. Comprehensive antenatal education birth preparation programmes to reduce the rates of caesarean section in nulliparous women. Protocol for an individual participant data prospective meta-analysis
Published 2020Introduction Rates of medical interventions in normal labour and birth are increasing. This prospective meta-analysis (PMA) proposes to assess whether the addition of a comprehensive multicomponent birth preparation programme ...Open AccessArticle -
Anti-coagulation, anti-platelets or no therapy in haemodialysis patients with atrial fibrillation: a decision analysis
Published 2013-12-01BACKGROUND: Optimal treatment of atrial fibrillation (AF) in the haemodialysis population is uncertain due to the exclusion of this group from randomized trials. The risk-benefit profile for anticoagulation and anti-platelet ...Open AccessArticle -
Anti-coagulation, anti-platelets or no therapy in haemodialysis patients with atrial fibrillation: A decision analysis
Published 2013-11-26NoneOpen AccessArticle -
Antiplatelet agents for preventing pre-eclampsia and its complications
Published 2019We set out to assess the ability of antiplatelet agents, such as aspirin and dipyridamole, to prevent women from developing pre-eclampsia during pregnancy and to improve health outcomes for them and their babies. We also ...Open AccessArticle -
Approaches to prioritising research for clinical trial networks: a scoping review
Published 2022Background Prioritisation of clinical trials ensures that the research conducted meets the needs of stakeholders, makes the best use of resources and avoids duplication. The aim of this review was to identify and critically ...Open AccessArticle -
Aspirin for preventing venous thromboembolism [commentary]
Published 2013-02-21Open AccessArticle, Letter -
Association between aircraft, road and railway traffic noise and depression in a large case-control study based on secondary data
Published 2017Background: Few studies have examined the relationship between traffic noise and depression providing inconclusive results. This large case-control study is the first to assess and directly compare depression risks by ...Open AccessArticle -
The association between socioeconomic status and cognitive development in children is partly mediated by a chaotic home atmosphere.
Published 2018There are socioeconomic-status (SES) differences in cognitive development. Various factors have been proposed that might explain this association, and one of these factors is the home environment. The present study examined ...Open AccessArticle -
Association of Contemporary Sensitive Troponin I Levels at Baseline and Change at 1 Year With Long-Term Coronary Events Following Myocardial Infarction or Unstable Angina : Results From the LIPID Study (Long-Term Intervention With Pravastatin in Ischaemic Disease)
Published 2013-09-30Objectives This study sought to assess whether baseline and change in contemporary sensitive troponin I (TnI) levels predicts coronary heart disease (CHD) death and myocardial infarction (MI), and to determine the effects ...Open AccessArticle -
Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
Published 2019Background Commercial or industry funding is associated with outcomes that favour the study funder in published studies, across various areas of research. However, it is currently unclear whether there are differences ...Open AccessArticle -
Barriers and facilitators to nurse-led advance care planning and palliative care practice change in primary healthcare: a qualitative study
Published 2022Primary care settings are ideal for initiating advance care planning (ACP) conversations and assessing palliative and supportive care needs. However, time constraints and a lack of confidence to sensitively and efficiently ...Open AccessArticle -
Benefits Of Oxygen Saturation Targeting Study (BOOST-II) dataset
Published 2023-06-27This dataset includes 1135 participants receiving either a lower (85 to 89%) or a higher (91 to 95%) oxygen-saturation range in 15 centres in Australia. Baseline data will include demographics, antenatal glucocorticoid ...Open AccessDataset -
Beta-blocker, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, nitrate-hydralazine, diuretics, aldosterone antagonist, ivabradine, devices and digoxin (BANDAID2): an evidence-based mnemonic for the treatment of systolic heart failure
Published 2015-06-26Heart failure causes significant morbidity and mortality, with recognised underutilisation rates of guideline based therapies. Our aim was to review current evidence for heart failure treatments and derive a mnemonic ...Open AccessArticle -
Can patient-led surveillance detect subsequent new primary or recurrent melanomas and reduce the need for routinely scheduled follow-up? A protocol for the MEL-SELF randomised controlled trial
Published 2021Background Most subsequent new primary or recurrent melanomas might be self-detected if patients are trained to systematically self-examine their skin and have access to timely medical review (patient-led surveillance). ...Open AccessArticle