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dc.contributor.authorMendez-Mendez, J.V.
dc.contributor.authorAlonso-Rasgado, M.T.
dc.contributor.authorCorreia Faria, E.
dc.contributor.authorFlores-Johnson, E.A.
dc.contributor.authorSnook, R.D.
dc.date.accessioned2014-06-24
dc.date.available2014-06-24
dc.date.issued2014-11-01
dc.identifier.citationMendez-Mendez, J.V.,Alonso-Rasgado, M.T. , Correia Faria, E. , Flores-Johnson, E.A. , Snook, R.D., Numerical study of the hydrodynamic drag force in atomic force microscopy measurements undertaken in fluids, Micron, Volume 66, November 2014, Pages 37-46en_AU
dc.identifier.urihttp://hdl.handle.net/2123/11418
dc.description.abstractWhen atomic force microscopy (AFM) is employed for in vivo study of immersed biological samples, the fluid medium presents additional complexities, not least of which is the hydrodynamic drag force due to viscous friction of the cantilever with the liquid. This force should be considered when interpreting experimental results and any calculated material properties. In this paper, a numerical model is presented to study the influence of the drag force on experimental data obtained from AFM measurements using computational fluid dynamics (CFD) simulation. The model provides quantification of the drag force in AFM measurements of soft specimens in fluids. The numerical predictions were compared with experimental data obtained using AFM with a V-shaped cantilever fitted with a pyramidal tip. Tip velocities ranging from 1.05 to 105 µm/s were employed in water, polyethylene glycol and glycerol with the platform approaching from a distance of 6000 nm. The model was also compared with an existing analytical model. Good agreement was observed between numerical results, experiments and analytical predictions. Accurate predictions were obtained without the need for extrapolation of experimental data. In addition, the model can be employed over the range of tip geometries and velocities typically utilized in AFM measurements.en_AU
dc.language.isoenen_AU
dc.publisherELSEVIERen_AU
dc.rightsAccepted Author Manuscript: Voluntary posting on open web sites operated by author or author's institution for scholarly purposes.en_AU
dc.subjectAtomic force microscopy (AFM)en_AU
dc.subjecthydrodynamic drag forceen_AU
dc.subjectcomputational fluid dynamics (CFD)en_AU
dc.subjectnumerical simulationen_AU
dc.titleNumerical study of the hydrodynamic drag force in atomic force microscopy measurements undertaken in fluidsen_AU
dc.typeArticleen_AU
dc.subject.asrc019909en_AU
dc.subject.asrc010301en_AU
dc.identifier.doi10.1016/j.micron.2014.05.004
dc.type.pubtypePost-printen_AU


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