|Title:||Numerical study of the hydrodynamic drag force in atomic force microscopy measurements undertaken in fluids|
Correia Faria, E.
|Keywords:||Atomic force microscopy (AFM)|
hydrodynamic drag force
computational fluid dynamics (CFD)
|Citation:||Mendez-Mendez, J.V.,Alonso-Rasgado, M.T. , Correia Faria, E. , Flores-Johnson, E.A. , Snook, R.D., Numerical study of the hydrodynamic drag force in atomic force microscopy measurements undertaken in fluids, Micron, Volume 66, November 2014, Pages 37-46|
|Abstract:||When atomic force microscopy (AFM) is employed for in vivo study of immersed biological samples, the fluid medium presents additional complexities, not least of which is the hydrodynamic drag force due to viscous friction of the cantilever with the liquid. This force should be considered when interpreting experimental results and any calculated material properties. In this paper, a numerical model is presented to study the influence of the drag force on experimental data obtained from AFM measurements using computational fluid dynamics (CFD) simulation. The model provides quantification of the drag force in AFM measurements of soft specimens in fluids. The numerical predictions were compared with experimental data obtained using AFM with a V-shaped cantilever fitted with a pyramidal tip. Tip velocities ranging from 1.05 to 105 µm/s were employed in water, polyethylene glycol and glycerol with the platform approaching from a distance of 6000 nm. The model was also compared with an existing analytical model. Good agreement was observed between numerical results, experiments and analytical predictions. Accurate predictions were obtained without the need for extrapolation of experimental data. In addition, the model can be employed over the range of tip geometries and velocities typically utilized in AFM measurements.|
|Rights and Permissions:||Accepted Author Manuscript: Voluntary posting on open web sites operated by author or author's institution for scholarly purposes.|
|Type of Work:||Article|
|Type of Publication:||Post-print|
|Appears in Collections:||Research Papers and Publications. Engineering and Information Technologies|
|JV Mendez-Mendez et al Micron 66 37-46.pdf||1.05 MB||Adobe PDF|
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