Sydney Digital Theses (University of Sydney Access only): Recent submissions
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Multidimensional profiling of cellular interactions in heart failure (HF) patients.
Published 2025Heart failure (HF) remains a major global health burden, with its subcellular pathophysiology still not fully understood. This thesis establishes an optimised Imaging Mass Cytometry (IMC) platform tailored to cardiac tissue, ...USyd AccessThesis -
The ecology of host-microbiota associations in sharks.
Published 2024The health and function of most multicellular eukaryotes is underpinned by innate associations with microorganisms. Understanding the interactions between eukaryotic hosts and their microbiota is particularly important ...USyd AccessThesis -
The Development of Novel Lung-Tropic AAVs to Support a Gene Therapy for Cystic Fibrosis
Published 2025Cystic fibrosis (CF) is a life-shortening disease that affects all mucosal surfaces of the body, with the more severe symptoms manifesting in the respiratory system. This monogenic disease is caused by a variety of mutations ...USyd AccessThesis -
Molecular Determinants of Treatment Response and Outcomes in Acute Myeloid Leukaemia with mutated NPM1
Published 2025Mutations in the nucleophosmin (NPM1) gene occur in ~30% of adult AML, where they define a distinct disease subtype associated with relatively favourable prognosis. Outcomes are impacted by age, mutations in FLT3-ITD and ...USyd AccessThesis -
An investigation of the environmental health risks from rural sanitation infrastructure: with a case study from Fiji
Published 2025Access to safely managed sanitation has emerged as a global challenge. Nearly half the global population lives in rural areas and generally relies on on-site sanitation systems. Sustainable Development Goal target 6.2 aims ...USyd AccessThesis