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    • Addenbrooke’s Cognitive Examination III: Psychometric Characteristics and Relations to Functional Ability in Dementia 

      So, Matthew; Foxe, David; Kumfor, Fiona; Murray, Cynthia; Hsieh, Sharpley; Savage, Greg; Ahmed, Rebekah M.; Burrell, James R.; Hodges, John R.; Irish, Muireann; Piguet, Olivier
      Published 2018-09-07
      Objectives: The Addenbrooke’s Cognitive Examination (ACE) is a common cognitive screening test for dementia. Here, we examined the relationship between the most recent version (ACE-III) and its predecessor (ACE-R), determined ...
      Open Access
      Article
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    • Age-related changes in the temporal focus and self-referential content of spontaneous cognition during periods of low cognitive demand 

      Irish, Muireann; Goldberg, Zoe-Lee; Alaeddin, Sara; O’Callaghan, Claire; Andrews-Hanna, Jessica R.
      Published 2019-09-18
      An intriguing aspect of human cognition is the unique capacity to mentally retreat from our immediate surroundings to consider perspectives distinct from the here and now. Despite increasing interest in this phenomenon, ...
      Open Access
      Article
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    • "All is not lost” - Rethinking the nature of memory and the self in dementia 

      Strikwerda-Brown, C.; Grilli, M.D.; Andrews-Hanna, J.R.; Irish, Muireann
      Published 2019-09-18
      Memory and the self have long been considered intertwined, leading to the assumption that without memory, there can be no self. This line of reasoning has led to the misconception that a loss of memory in dementia necessarily ...
      Open Access
      Article
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    • Association between precuneus volume and autobiographical memory impairment in posterior cortical atrophy: Beyond the visual syndrome 

      Ahmed, Samrah; Irish, Muireann; Loane, Clare; Baker, Ian; Husain, Masud; Thompson, Sian; Blanco-Duque, Cristina; Mackay, Clare; Zamboni, Giovanna; Foxe, David; Hodges, John R.; Piguet, Olivier; Butler, Christopher
      Published 2018-03-10
      Posterior cortical atrophy is a neurodegenerative syndrome characterised by progressive disruption of visual and perceptual processing, associated with atrophy in the parieto-occipital cortex. Current diagnostic criteria ...
      Open Access
      Article
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    • Cerebellar Atrophy and Its Contribution to Cognition in Frontotemporal Dementias 

      Chen, Yu; Kumfor, Fiona; Landin-Romero, Ramon; Irish, Muireann; Hodges, John R.; Piguet, Olivier
      Published 2018-06-07
      Objective: Increasing evidence suggests that cerebellar damage impacts on cognitive functions. Frontotemporal dementias (FTDs) are neurodegenerative brain conditions, primarily affecting the frontal and/or temporal lobe. ...
      Open Access
      Article
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    • The cerebellum in frontotemporal dementia: a meta-analysis of neuroimaging studies 

      Chen, Y.; Kumfor, F.; Landin-Romero, R.; Irish, Muireann; Piguet, O.
      Published 2019-08-19
      Frontotemporal dementia (FTD) is a neurodegenerative brain disorder primarily affecting the frontal and/or temporal lobes. Three main subtypes have been recognized: behavioural-variant FTD (bvFTD), semantic dementia (SD) ...
      Article
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    • Conditioned inhibition and reinforcement rate 

      Harris, Justin A; Kwok, Dorothy; Andrew, Benjamin J
      Published 2014-01-01
      We investigated conditioned inhibition in a magazine approach paradigm. Rats were trained on a feature negative discrimination between an auditory conditioned stimulus (CS) reinforced at one rate versus a compound of that ...
      Open Access
      Article
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    • Exploring the contribution of visual imagery to scene construction – evidence from Posterior Cortical Atrophy 

      Ramanan, Siddharth; Alaeddin, Sara; Goldberg, Zoe-Lee; Strikwerda-Brown, Cherie; Hodges, John R.; Irish, Muireann
      Published 2018-09-01
      Posterior Cortical Atrophy (PCA) is a rare neurodegenerative syndrome characterised by profound visuoperceptual processing disturbances, attributable to focal parieto-occipital cortical atrophy. Despite relative sparing ...
      Open Access
      Article
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    • External details revisited – A new taxonomy for coding ‘non-episodic’ content during autobiographical memory retrieval 

      Strikwerda-Brown, Cherie; Mothakunnel, Annu; Hodges, John R.; Piguet, Olivier; Irish, Muireann
      Published 2018-04-24
      Autobiographical memory is typically held to comprise episodic and semantic elements, with the vast majority of studies to date focusing on profiles of episodic details in health and disease. In this context, ‘non-episodic’ ...
      Open Access
      Article
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    • Fronto-parietal contributions to episodic retrieval – evidence from neurodegenerative disorders 

      Ramananan, Siddharth; Strikwerda-Brown, Cherie; Mothakunnelel, Annu; Hodges, John R.; Piguet, Olivier; Irish, Muireann
      Published 2019-06-01
      Converging evidence suggests a critical role for the parietal cortices in episodic memory retrieval. Here, we examined episodic memory performance in Corticobasal Syndrome (CBS), a rare neurodegenerative disorder presenting ...
      Open Access
      Article
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    • The function of prospection - variations in health and disease 

      Bulley, Adam; Irish, Muireann
      Published 2018-11-27
      Much of human life revolves around anticipating and planning for the future. It has become increasingly clear that this capacity for prospective cognition is a core adaptive function of the mind. Here, we review the role ...
      Open Access
      Article
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    • Hippocampal atrophy and intrinsic brain network alterations relate to impaired capacity for mind wandering in neurodegeneration 

      O’Callaghan, C.; Shine, J.M.; Hodges, J.R.; Andrews-Hanna, J.R.; Irish, Muireann
      Published 2019-09-18
      Mind wandering represents the human capacity for internally focussed thought, and relies upon dynamic interactions between default and frontoparietal networks. The majority of studies in the field have characterised mind ...
      Open Access
      Article
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    • Neurocognitive mechanisms of theory of mind impairment in neurodegeneration: a transdiagnostic approach 

      Strikwerda-Brown, Cherie; Ramanan, Siddharth; Irish, Muireann
      Published 2019-02-20
      Much of human interaction is predicated upon our innate capacity to infer the thoughts, beliefs, emotions, and perspectives of others, in short, to possess a “theory of mind” (ToM). While the term has evolved considerably ...
      Open Access
      Article
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    • The other side of the coin – Semantic dementia as a lesion model for understanding recollection and familiarity 

      Strikwerda-Brown, C.; Irish, Muireann
      Published 2019-09-18
      The syndrome of semantic dementia represents the “other side of the coin” to Alzheimer’s disease, offering convergent evidence to help refine Bastin et al.’s Integrative Memory Model. By considering the Integrative Memory ...
      Open Access
      Article, Letter
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    • Rethinking the role of the angular gyrus in remembering the past and imagining the future - the Contextual Integration Model 

      Ramanan, Siddharth; Piguet, Olivier; Irish, Muireann
      Published 2017-10-18
      Despite consistent activation on tasks of episodic memory, the precise contribution of the left angular gyrus (AG) to mnemonic functions remains vigorously debated. Mounting evidence suggests that AG activity scales with ...
      Open Access
      Article
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    • Supporting data: Validation of a Bayesian adaptive estimation technique in the stop-signal task 

      Livesey, Evan J.; Livesey, David J.
      Published 2016-11-11
      The Stop Signal Task (SST), a commonly used measure of response inhibition, uses standard psychophysical methods to gain an estimate of the time needed to withhold a prepotent response. Under some circumstances, conventional ...
      Open Access
      Dataset
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    • "Truth be told” – Semantic memory as the scaffold for veridical communication 

      Hayes, Brett K.; Ramanan, Siddharth; Irish, Muireann
      Published 2018-01-22
      Theoretical accounts placing episodic memory as central to constructive and communicative functions neglect the role of semantic memory. We argue that the decontextualized nature of semantic schemas largely supersedes the ...
      Open Access
      Article, Letter
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    • Visuospatial dysfunction in Alzheimer’s disease and behavioural variant frontotemporal dementia 

      Salimi, S.; Irish, Muireann; Foxe, D.; Hodges, J.R.; Piguet, O.; Burrell, J.R.
      Published 2019-09-18
      OBJECTIVES: Approximately 30% of Alzheimer’s disease (AD) patients are misdiagnosed due to overlapping and evolving clinical features. In particular, the distinction of AD from behavioural variant frontotemporal dementia ...
      Open Access
      Article
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