Research Publications and Outputs: Recent submissions
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Modelling associations between neurocognition and functional course in young people with emerging mental disorders: a longitudinal cohort study
Published 2020-01-21Neurocognitive impairment is commonly associated with functional disability in established depressive, bipolar and psychotic disorders. However, little is known about the longer-term functional implications of these ...Open AccessArticle -
Mycobacterium marinum infection drives foam cell differentiation in zebrafish infection models
Published 2018-11-01Host lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic ...Open AccessArticle -
Revisiting hypoxia therapies for tuberculosis
Published 2019-06-17The spectre of the coming post-antibiotic age demands novel therapies for infectious diseases. Tuberculosis, caused by Mycobacterium tuberculosis, is the single deadliest infection throughout human history. M. tuberculosis ...Open AccessArticle -
The cyclic nitroxide antioxidant 4-methoxy-TEMPO decreases mycobacterial burden in vivo through host and bacterial targets
Published 2019-05-01Tuberculosis is a chronic inflammatory disease caused by persistent infection with Mycobacterium tuberculosis. The rise of antibiotic resistant strains necessitates the design of novel treatments. Recent evidence shows ...Open AccessArticle -
Analysis of mycobacterial infection-induced changes to host lipid metabolism in a zebrafish infection model reveals a conserved role for LDLR in infection susceptibility
Published 2018-12-01Changes to lipid metabolism are well-characterised consequences of human tuberculosis infection but their functional relevance are not clearly elucidated in these or other host-mycobacterial systems. The zebrafish-Mycobacterium ...Open AccessArticle