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MLC tracking for lung SABR reduces planning target volumes and dose to organs at risk.

Caillet, V; Keall, P; Colvill, E; Hardcastle, N; O'Brien, R; Szymura, K; Booth, JT (Elsevier, 2017-07)

PURPOSE: Assess the dosimetric impact of multi-leaf collimator (MLC) tracking and mid-ventilation (midV) planning compared with the internal target volume (ITV)-based planning approach for lung Stereotactic Ablative Body ...

Imaging performance of a dedicated radiation transparent RF coil on a 1.0 Tesla inline MRI-linac.

Liney, GP; Dong, B; Weber, E; Rai, R; Destruel, A; Garcia-Alvarez, R; Manton, DJ; Jelen, U; Zhang, K; Barton, M; Keall, P; Crozier, S (IOPscience, 2018-06)

This work describes the first imaging studies on a 1.0 Tesla inline MRI-Linac using a dedicated transmit/receive RF body coil that has been designed to be completely radio transparent and provide optimum imaging performance ...

A CBCT study of the gravity-induced movement in rotating rabbits.

Barber, J; Shieh, CC; Counter, W; Sykes, J; Bennett, P; Ahern, V; Corde, S; Heng, SM; White, P; Jackson, M; Liu, P; Keall, P; Feain, I (2018-05)

Fixed-beam radiotherapy systems with subjects rotating about a longitudinal (horizontal) axis are subject to gravity-induced motion. Limited reports on the degree of this motion, and any deformation, has been reported ...

Performance assessment of a programmable five degrees-of-freedom motion platform for quality assurance of motion management techniques in radiotherapy.

Huang, CY; Keall, P; Rice, A; Colvill, E; Ng, JA; Booth, JT (Springer, 2017-09)

Inter-fraction and intra-fraction motion management methods are increasingly applied clinically and require the development of advanced motion platforms to facilitate testing and quality assurance program development. The ...

Evaluating the accuracy of 4D-CT ventilation imaging: First comparison with Technegas SPECT ventilation.

Hegi-Johnson, F; Keall, P; Barber, J; Bui, C; Kipritidis, J (Wiley, 2017-08)

PURPOSE: Computed tomography ventilation imaging (CTVI) is a highly accessible functional lung imaging modality that can unlock the potential for functional avoidance in lung cancer radiation therapy. Previous attempts ...

Future of medical physics: Real-time MRI-guided proton therapy.

Oborn, BM; Dowdell, S; Metcalfe, PE; Crozier, S; Mohan, R; Keall, P (Wiley, 2017-08)

With the recent clinical implementation of real-time MRI-guided x-ray beam therapy (MRXT), attention is turning to the concept of combining real-time MRI guidance with proton beam therapy; MRI-guided proton beam therapy ...

The first clinical implementation of real-time image-guided adaptive radiotherapy using a standard linear accelerator.

Keall, P; Nguyen, DT; O'Brien, R; Caillet, V; Hewson, E; Poulsen, PR; Bromley, R; Bell, L; Eade, T; Kneebone, A; Martin, J; Booth, JT (Elsevier, 2018-04)

PURPOSE: Until now, real-time image guided adaptive radiation therapy (IGART) has been the domain of dedicated cancer radiotherapy systems. The purpose of this study was to clinically implement and investigate real-time ...

Commissioning and quality assurance for VMAT delivery systems: An efficient time-resolved system using real-time EPID imaging.

Zwan, BJ; Barnes, MP; Hindmarsh, J; Lim, SB; Lovelock, DM; Fuangrod, T; O'Connor, DJ; Keall, P; Greer, PB (Wiley, 2017-08)

PURPOSE: An ideal commissioning and quality assurance (QA) program for Volumetric Modulated Arc Therapy (VMAT) delivery systems should assess the performance of each individual dynamic component as a function of gantry ...

Investigating multi-leaf collimator tracking in stereotactic arrhythmic radioablation (STAR) treatments for atrial fibrillation.

Lydiard, S; Caillet, V; Ipsen, S; O'Brien, R; Blanck, O; Poulsen, PR; Booth, J; Keall, P (IOPscience, 2018-09)

Stereotactic arrhythmia radioablation (STAR) is an emerging treatment option for atrial fibrillation (AF). However, it faces possibly the most challenging motion compensation scenario: both respiratory and cardiac ...

Technical Note: Real-time image-guided adaptive radiotherapy of a rigid target for a prototype fixed beam radiotherapy system.

Liu, P; Nguyen, DT; Feain, I; O'Brien, R; Keall, P; Booth, JT (Wiley, 2018-10)

PURPOSE: Fixed beam radiotherapy systems utilize couch movement and rotation instead of gantry rotation in order to simplify linear accelerator design. We investigate the ability to deliver fixed beam treatments with the ...