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  • Recent submissions
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Research Publications and Outputs: Recent submissions

    • Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes 

      Khatib, Isra; Ke, Wei-Ren; Cipolla, David; Chan, Hak-Kim
      Published 2021
      Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) were recently developed. In the present study, the storage stability of CNL powders consisting of lyoprotectant ...
      Open Access
      Article
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    • Ciprofloxacin nanocrystals liposomal powders for controlled drug release via inhalation 

      Khatib, Isra; Khanal, Dipesh; Ruan, Juanfang; Cipolla, David; Dayton, Francis; Blanchard, James; Chan, Hak-Kim
      Published 2019
      This study was conducted to evaluate the feasibility of developing inhalable dry powders of liposomal encapsulated ciprofloxacin nanocrystals (LECN) for controlled drug release. Dry powders of LECN were produced by freeze-thaw ...
      Open Access
      Article
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    • Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design 

      Khatib, Isra; Chow, Michael YT; Ruan, Juanfang; Cipolla, David; Chan, Hak-Kim
      Published 2021
      Spray drying was previously used to modify the physical form of the encapsulated ciprofloxacin drug to produce ciprofloxacin nanocrystals inside the liposomes (CNL). The purpose of the present study was to optimize CNL ...
      Open Access
      Article
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    • Formation of ciprofloxacin nanocrystals within liposomes by spray drying for controlled release via inhalation 

      Khatib, Isra; Tang, Patricia; Ruan, Juanfang; Cipolla, David; Dayton, Francis; Blanchard, James; Chan, Hak-Kim
      Published 2020
      The present study was conducted to harness spray drying technology as a novel method of producing Ciprofloxacin nanocrystals inside liposomes (CNL) for inhalation delivery. Liposomal ciprofloxacin dispersions were spray ...
      Open Access
      Article
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    • Nanoscale probing of liposome encapsulating drug nanocrystal using Atomic Force Microscopy-Infrared Spectroscopy 

      Khanal, Dipesh; Khatib, Isra; Ruan, Juanfang; Cipolla, David; Dayton, Francis; Blanchard, James; Chan, Hak-Kim; Chrzanowski, Wojciech
      Published 2020
      Use of liposomes encapsulating drug nanocrystals for the treatment of diseases like cancer and pulmonary infections is gaining attention. The potential therapeutic benefit of these engineered formulations relies on maintaining ...
      Open Access
      Article
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