Browsing Sydney Pharmacy School by subject "1115 Pharmacology and Pharmaceutical Sciences"
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Ciprofloxacin nanocrystals liposomal powders for controlled drug release via inhalation
Published 2019This study was conducted to evaluate the feasibility of developing inhalable dry powders of liposomal encapsulated ciprofloxacin nanocrystals (LECN) for controlled drug release. Dry powders of LECN were produced by freeze-thaw ...Open AccessArticle -
The effect of device resistance and inhalation flow rate on the lung deposition of orally inhaled mannitol dry powder
Published 2016-01-01The present study investigates the effect of DPI resistance and inhalation flow rates on the lung deposition of orally inhaled mannitol dry powder. Mannitol powder radiolabeled with 99mTc-DTPA was inhaled from an Osmohaler™ ...Open AccessArticle -
Effect of Spacers on the Bipolar Electrostatic Charge Properties of Metered Dose Inhaler Aerosols-A Case Study With Tilade ®
Published 2017-01-01Aerosols emitted from metered dose inhalers (MDIs) are generally electrically charged and bipolar in nature. Although a spacer can effectively dampen the charge magnitude of aerosols, the electrostatic interactions between ...Open AccessArticle -
Formation of ciprofloxacin nanocrystals within liposomes by spray drying for controlled release via inhalation
Published 2020The present study was conducted to harness spray drying technology as a novel method of producing Ciprofloxacin nanocrystals inside liposomes (CNL) for inhalation delivery. Liposomal ciprofloxacin dispersions were spray ...Open AccessArticle -
Modeling of a spray drying method to produce ciprofloxacin nanocrystals inside the liposomes utilizing a response surface methodology: Box-Behnken experimental design
Published 2021Spray drying was previously used to modify the physical form of the encapsulated ciprofloxacin drug to produce ciprofloxacin nanocrystals inside the liposomes (CNL). The purpose of the present study was to optimize CNL ...Open AccessArticle -
Nanoscale probing of liposome encapsulating drug nanocrystal using Atomic Force Microscopy-Infrared Spectroscopy
Published 2020Use of liposomes encapsulating drug nanocrystals for the treatment of diseases like cancer and pulmonary infections is gaining attention. The potential therapeutic benefit of these engineered formulations relies on maintaining ...Open AccessArticle -
Nebulised Isotonic Hydroxychloroquine Aerosols for Potential Treatment of COVID-19
Published 2021The coronavirus disease 2019 (COVID-19) is an unprecedented pandemic that has severely impacted global public health and the economy. Hydroxychloroquine administered orally to COVID-19 patients was ineffective, but its ...Article -
Protective effect of sodium stearate on the moisture-induced deterioration of hygroscopic spray-dried powders
Published 2018-01-01Amorphous powders are thermodynamically unstable, significantly impacting the processing, storage and performance of a product. Therefore, stabilization of the amorphous contents is in demand. In this study, disodium ...Open AccessArticle -
The state-of-play and future of platinum drugs
Published 2015-08The year 2015 marks the 50th anniversary since the discovery of the anticancer potential of cisplatin and it remains just as useful now as it did back then, especially for the treatment of some endocrine-related cancers ...Open AccessArticle -
Storage stability of inhalable, controlled-release powder formulations of ciprofloxacin nanocrystal-containing liposomes
Published 2021Novel inhalable and controlled release powder formulations of ciprofloxacin nanocrystals inside liposomes (CNL) were recently developed. In the present study, the storage stability of CNL powders consisting of lyoprotectant ...Open AccessArticle -
Studies of Radioaerosol Deposition in the Respiratory Tract
Published January 20Deposition of aerosols in the respiratory tract can be quantitatively and qualitatively studied by scintigraphy. The most commonly used radionuclide for this purpose is technetium-99m. The effects of various factors on ...Open AccessArticle