School of Medical Sciences: Recent submissions
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A cross-study transcriptional analysis of Parkinson's disease
Published 2009-01-01The study of Parkinson's disease (PD), like other complex neurodegenerative disorders, is limited by access to brain tissue from patients with a confirmed diagnosis. Alternatively the study of peripheral tissues may offer ...Open AccessArticle -
A mutation in bovine keratin 5 causing epidermolysis bullosa simplex, transmitted by a mosaic sire
Published 2005-01-01A mechanobullous skin disorder was identified in the progeny of a 3-y-old Friesian-Jersey crossbred bull. The condition presented as loss of skin and mucosa from contact areas and inflammation. Examination of skin samples ...Open AccessArticle -
Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
Published 2009-01-01Recent whole genome association studies provided little evidence that polymorphisms at the familial Parkinsonism loci influence the risk for Parkinson's disease (PD). However, these studies are not designed to detect the ...Open AccessArticle -
Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
Published 2009-01-01Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence ...Open AccessArticle -
Disease-specific, neurosphere-derived cells as models for brain disorders
Published 2010-01-01There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new ...Open AccessArticle