• High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens 

      Counoupas, Claudio; Pino, Paco; Stella, Alberto O.; Ashley, Caroline; Lukeman, Hannah; Bhattacharyya, Nayan D.; Tada, Takuya; Anchisi, Stephanie; Metayer, Charles; Martinis, Jacopo; Aggarwal, Anupriya; Dcosta, Belinda M.; Britton, Warwick J.; Kint, Joeri; Wurm, Maria J.; Landau, Nathaniel R.; Steain, Megan; Turville, Stuart G.; Wurm, Florian M.; David, Sunil A.; Triccas, James A.
      Published 2022
      Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine that ...
      Article
    • Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens 

      He, Wan-Ting; Hou, Xin; Zhao, Jin; Sun, Jiumeng; He, Haijian; Si, Wei; Wang, Jing; Jiang, Zhiwen; Yan, Ziqing; Xing, Gang; Lu, Meng; Suchard, Marc A.; Ji, Xiang; Gong, Wenjie; He, Biao; Li, Jun; Lemey, Philippe; Guo, Deyin; Tu, Changchun; Holmes, Edward C.; Shi, Mang; Su, Shuo
      Published 2021
      Game animals are wildlife species often traded and consumed as exotic food, and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1725 game animals, representing 16 species ...
      Preprint
    • Emergence and spread of SARS-CoV-2 lineages B.1.1.7 and P.1 in Italy 

      Di Giallonardo, Francesca; Puglia, Ilaria; Curini, Valentina; Cammà, Cesare; Mangone, Iolanda; Calistri, Paolo; Cobbin, Joanna C.A.; Holmes, Edward C.; Lorusso, Alessio
      Published 2021
      Italy’s second wave of SARS-CoV-2 has hit hard, with more than 3 million cases and over 100,000 deaths, representing an almost ten-fold increase on the numbers reported by August 2020. Herein, we present the analysis of ...
      Preprint
    • The impact of public health interventions in the Nordic countries during the first year of SARS-CoV-2 transmission and evolution. 

      Duchene, Sebastian; Featherstone, Leo; Freiesleben de Blasio, Birgitte; Holmes, Edward C.; Bohlin, Jon; Pettersson, John H-O
      Published 2021
      BackgroundMany countries have attempted to mitigate and control COVID-19 through non-pharmaceutical interventions, particularly with the aim of reducing population movement and contact. However, it remains unclear how the ...
      Article
    • Pathogenicity and transmissibility of a novel respirovirus isolated from a Malayan pangolin. 

      Yang, Rou; Peng, Jinyu; Zhai, Junqiong; Xiao, Kangpeng; Zhang, Xu; Li, Xiaobing; Chen, Xiaoyuan; Chen, Zu-Jin; Holmes, Edward C.; Irwin, David M.; Shan, Fen; Shen, Xuejuan; Chen, Wu; Shen, Yongyi
      Published 2021
      The identification of SARS-CoV-2-like viruses in Malayan pangolins (Manis javanica) has focused attention on these endangered animals and the viruses they carry. We successfully isolated a novel respirovirus from the lungs ...
      Article