Developing Frameworks for Nanotechnology driven DNA-Free Plant Gene-Editing

Abstract

The bottlenecks of conventional plant gene-editing methods gave an innovative rise to nanotechnology as a delivery tool to manipulate gene(s) of interest. Studies suggest a strong correlation between the physicochemical properties of nanomaterials and their efficiency in gene delivery to different plant species/tissues. In this opinion we highlight the need for a deeper understanding of plant-nanomaterial interactions to align their full capabilities with the strategic goals of plant gene-editing. Additionally, we emphasise DNA-free plant gene-editing approaches to potentially mitigate concerns surrounding genetically modified organisms (GMOs). Lastly, we propose a strategic integration of the principles of responsible research and innovation (RRI) in R&D. We aim to initiate a dialogue on developing collaborative and socio-technical frameworks for nanotechnology and DNA-free plant gene-editing.