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dc.contributor.authorSmit, Amelia K.
dc.contributor.authorAllen, Martin
dc.contributor.authorBeswick, Brooke
dc.contributor.authorButow, Physllis
dc.contributor.authorDawkins, Hugh
dc.contributor.authorDobbinson, Suzanne J.
dc.contributor.authorDunlop, Kate L.
dc.contributor.authorEspinoza, David
dc.contributor.authorFenton, Georgina
dc.contributor.authorKanetsky, Peter A.
dc.contributor.authorKeogh, Louise
dc.contributor.authorKimlin, Michael G.
dc.contributor.authorKirk, Judy
dc.contributor.authorLaw, Matthew H.
dc.contributor.authorLo, Serigne
dc.contributor.authorLow, Cynthia
dc.contributor.authorMann, Graham J.
dc.contributor.authorReyes-Marcelino, Gillian
dc.contributor.authorMorton, Rachael L.
dc.contributor.authorNewson, Ainsley J.
dc.contributor.authorSavard, Jacqueline
dc.contributor.authorTrevena, Lyndal
dc.contributor.authorWordsworth, Sarah
dc.contributor.authorCust, Anne E.
dc.date.accessioned2023-03-28T05:42:16Z
dc.date.available2023-03-28T05:42:16Z
dc.date.issued2021en_AU
dc.identifier.urihttps://hdl.handle.net/2123/31043
dc.description.abstractPurpose We evaluated the impact of personal melanoma genomic risk information on sun-related behaviors and psychological outcomes. Methods In this parallel group, open, randomized controlled trial, 1,025 Australians of European ancestry without melanoma and aged 18–69 years were recruited via the Medicare database (3% consent). Participants were randomized to the intervention (n = 513; saliva sample for genetic testing, personalized melanoma risk booklet based on a 40-variant polygenic risk score, telephone-based genetic counseling, educational booklet) or control (n = 512; educational booklet). Wrist-worn ultraviolet (UV) radiation dosimeters (10-day wear) and questionnaires were administered at baseline, 1 month postintervention, and 12 months postbaseline. Results At 12 months, 948 (92%) participants completed dosimetry and 973 (95%) the questionnaire. For the primary outcome, there was no effect of the genomic risk intervention on objectively measured UV exposure at 12 months, irrespective of traditional risk factors. For secondary outcomes at 12 months, the intervention reduced sunburns (risk ratio: 0.72, 95% confidence interval: 0.54–0.96), and increased skin examinations among women. Melanoma-related worry was reduced. There was no overall impact on general psychological distress. Conclusion Personalized genomic risk information did not influence sun exposure patterns but did improve some skin cancer prevention and early detection behaviors, suggesting it may be useful for precision prevention. There was no evidence of psychological harm.en_AU
dc.language.isoenen_AU
dc.publisherGenetics in Medicineen_AU
dc.rightsCreative Commons Attribution 4.0en_AU
dc.subjectPersonalen_AU
dc.subjectGenomic Risken_AU
dc.subjectMelanomaen_AU
dc.subjectPreventionen_AU
dc.subjectPsychologicalen_AU
dc.subjectOutcomesen_AU
dc.subjectRandomized Trialen_AU
dc.titleImpact of personal genomic risk information on melanoma prevention behaviors and psychological outcomes: a randomized controlled trialen_AU
dc.typeArticleen_AU
dc.identifier.doihttps://doi.org/10.1038/s41436-021-01292-w
dc.type.pubtypePublisher's versionen_AU
usyd.facultyFaculty of Medicine and Healthen_AU
usyd.departmentNHMRC Clinical Trials Centreen_AU
workflow.metadata.onlyNoen_AU


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