Browsing Research Publications and Outputs by publication year
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Research Report 2004–2005
Published 2006-01-01The National Health and Medical Research Council Clinical Trials Centre has the purpose of improving outcomes in health through clinical trials research. It was established by the National Health and Medical Research Council ...Open AccessReport, Technical -
Research Report 2006–2007
Published 2008-01-01The National Health and Medical Research Council Clinical Trials Centre conducts its own clinical trials, provides expertise and infrastructure for trials run by other groups, and undertakes research aiming to improve both ...Open AccessReport, Technical -
Research Report 2008–2009
Published 2010-01-01The NHMRC Clinical Trials Centre at the University of Sydney runs large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes ...Open AccessReport, Technical -
Research Report 2010
Published 2011-01-01The NHMRC Clinical Trials Centre at the University of Sydney conducts large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes ...Open AccessReport, Technical -
Estimated glomerular filtration rate and albuminuria are independent predictors of cardiovascular events and death in type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Published 2011-01-01Background We investigated effects of renal function and albuminuria on cardiovascular outcomes in 9795 low-risk patients with diabetes in the Fenofibrate Intervention and Event Lowering in Diabetes study. Methods Baseline ...Open AccessArticle -
Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study
Published 2011-02-01Abstract Aims/hypothesis Fenofibrate caused an acute, sustained plasma creatinine increase in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and Action to Control Cardiovascular Risk in Diabetes ...Open AccessPost-print -
Single-agent irinotecan or FOLFIRI as second-line chemotherapy for advanced colorectal cancer; results of a randomised phase II study (DaVINCI) and meta-analysis
Published 2011-06-10Background Second-line treatment with irinotecan for advanced or metastatic colorectal cancer prolongs survival. It is uncertain whether irinotecan is better administered with 5- fluorouracil or alone in patients previously ...Open AccessArticle -
Phase II trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy
Published 2011-08-02Concurrent and post-radiotherapy temozolomide (T) significantly improves survival in patient with newly diagnosed glioblastoma multiforme. We aimed to assess the activity of the combination of T and pegylated liposomal ...Open AccessArticle -
Psychosocial aspects of post-treatment follow-up for stage I/II melanoma: a systematic review of the literature
Published 2012Patients treated for melanoma are advised to have lifelong full body skin examinations. Extended intervals between examinations have been proposed, but although this may be clinically effective, psychosocial aspects of ...Open AccessArticle -
Shared care in the follow-up of early-stage melanoma: qualitative study of melanoma clinicians' perspectives and models of care.
Published 2012Patients with early stage melanoma have high survival rates but require long-term follow-up to detect recurrences and/or new primary tumours. Shared care between melanoma specialists and general practitioners is an ...Open AccessArticle -
Research Report 2011
Published 2012-01-01The NHMRC Clinical Trials Centre (CTC) at the University of Sydney runs large multicentre investigator-initiated clinical trials, takes part in trials of national and international collaborative trial groups and contributes ...Open AccessReport, Technical -
Commentary on 'Case for BJOG compliance with prospective trial registration
Published 2012-01-01Prospective registration of clinical trials before enrolment of the first participant is an ethical and scientific. Registering clinical trials reduces duplication of research and aids better identification of gaps in our ...Open AccessArticle -
Using patient management as a surrogate for patient health outcomes in diagnostic test evaluation
Published 2012-01-01Background: Before a new test is introduced in clinical practice, evidence is needed to demonstrate that its use will lead to improvements in patient health outcomes. Studies reporting test accuracy may not be sufficient, ...Open AccessArticle -
Linking the evidence: intermediate outcomes in medical test assessments
Published 2012-01-01Objectives To review how health technology assessments (HTA) of medical tests incorporate intermediate outcomes in conclusions about the effectiveness of tests on improving health outcomes. Methods Systematic review of ...Open AccessPost-print -
Lack of effect of lowering LDL cholesterol on cancer: meta-analysis of individual data from 175,000 people in 27 randomised trials of statin therapy
Published 2012-01-19Background: Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL ...Open AccessArticle -
Effects of fenofibrate on cardiovascular events in patients with diabetes, with and without prior cardiovascular disease: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
Published 2012-02-01Background In the FIELD study, comparison of the effect of fenofibrate on cardiovascular disease (CVD) between those with prior CVD and without was a prespecified subgroup analysis. Methods The effects of fenofibrate on ...Open AccessArticle -
Which dialysis modality do patients approaching end-stage kidney disease prefer? Findings from a discrete choice study.
Published 2012-03-13BACKGROUND: Dialysis modality preferences of patients with chronic kidney disease (CKD) and family caregivers are important, yet rarely quantified. STUDY DESIGN: Prospective, unlabeled, discrete-choice experiment with ...Open AccessArticle -
Psychosocial aspects of post-treatment follow-up for stage I/II melanoma: a systematic review of the literature
Published 2012-03-19BACKGROUND: Patients treated for melanoma are advised to have lifelong full body skin examinations. Extended intervals between examinations have been proposed, but although this may be clinically effective, psychosocial ...Open AccessArticle -
Plasma homocysteine and the risk of venous thromboembolism: insights from the FIELD study
Published 2012-07-15Background The lipid-lowering effect of fenofibrate is accompanied by a rise in plasma homocysteine, a potential risk factor for venous thromboembolism (VTE). This study investigated the relationship between homocysteine ...Open AccessArticle -
Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study
Published 2012-10-20Background Small vessel disease is reported to be a more common cause of ischaemic stroke in people with diabetes than in others. However, population based studies have shown no difference between those with and those ...Open AccessArticle