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dc.contributor.authorSteffens, Daniel
dc.contributor.authorYoung, Jane
dc.contributor.authorRiedel, Bernhard
dc.contributor.authorMorton, Rachael
dc.contributor.authorDenehy, Linda
dc.contributor.authorHeriot, Alexander
dc.contributor.authorKoh, Cherry
dc.contributor.authorLi, Qiang
dc.contributor.authorBauman, Adrian
dc.contributor.authorSandroussi, Charbel
dc.contributor.authorIsmail, Hilmy
dc.contributor.authorDieng, Mbathio
dc.contributor.authorAnsari, Nabila
dc.contributor.authorO'Shannassy, Sarah
dc.contributor.authorMcKeown, Sam
dc.contributor.authorCunningham, Derek
dc.contributor.authorSheehan, Kym
dc.contributor.authorIori, Gino
dc.contributor.authorBartyn, Jenna
dc.contributor.authorSolomon, Michael
dc.date.accessioned2023-03-20T04:26:52Z
dc.date.available2023-03-20T04:26:52Z
dc.date.issued2022en_AU
dc.identifier.urihttps://hdl.handle.net/2123/30250
dc.description.abstractBackground Radical surgery is the mainstream treatment for patients presenting with advanced primary or recurrent gastrointestinal cancers; however, the rate of postoperative complications is exceptionally high. The current evidence suggests that improving patients’ fitness during the preoperative period may enhance postoperative recovery. Thus, the primary aim of this study is to establish the effectiveness of prehabilitation with a progressive, individualised, preoperative exercise and education program compared to usual care alone in reducing the proportion of patients with postoperative in-hospital complications. The secondary aims are to investigate the effectiveness of the preoperative intervention on reducing the length of intensive care unit and hospital stay, improving quality of life and morbidity, and reducing costs. Methods This is a multi-centre, assessor-blinded, pragmatic, comparative, randomised controlled trial. A total of 172 patients undergoing pelvic exenteration, cytoreductive surgery, oesophagectomy, hepatectomy, gastrectomy or pancreatectomy will be recruited. Participants will be randomly allocated to prehabilitation with a preoperative exercise and education program (intervention group), delivered over 4 to 8 weeks before surgery by community physiotherapists/exercise physiologists, or usual care alone (control group). The intervention will comprise 12 to 24 individualised, progressive exercise sessions (including aerobic/anaerobic, resistance, and respiratory exercises), recommendations of home exercises (16 to 32 sessions), and daily incidental physical activity advice. Outcome measures will be collected at baseline, the week prior to surgery, during the hospital stay, and on the day of discharge from hospital, and 1 month and 1 months postoperatively. The primary outcome will be the development of in-hospital complications. Secondary outcomes include the length of intensive care unit and hospital stay, quality of life, postoperative morbidity and costs. Discussion The successful completion of this trial will provide robust and high-quality evidence on the efficacy of a preoperative community- and home-based exercise and education intervention on important postoperative outcomes of patients undergoing major gastrointestinal cancer surgery.en_AU
dc.language.isoenen_AU
dc.publisherBMC Canceren_AU
dc.rightsCreative Commons Attribution 4.0en_AU
dc.subjectPreoperativeen_AU
dc.subjectPrehabilitationen_AU
dc.subjectExerciseen_AU
dc.subjectEducationen_AU
dc.subjectCanceren_AU
dc.subjectSurgeryen_AU
dc.subjectGastrointestinalen_AU
dc.subjectComplicationsen_AU
dc.subjectRandomised controlled trialen_AU
dc.titlePRehabIlitatiOn with pReoperatIve exercise and educaTion for patients undergoing major abdominal cancer surgerY: protocol for a multicentre randomised controlled TRIAL (PRIORITY TRIAL)en_AU
dc.typeArticleen_AU
dc.identifier.doihttps://doi.org/10.1186/s12885-022-09492-6
dc.type.pubtypePublisher's versionen_AU
usyd.facultyFaculty of Medicine and Healthen_AU
usyd.departmentNHMRC Clinical Trials Centreen_AU
workflow.metadata.onlyNoen_AU


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