Monitoring Initial Response to Angiotensin-Converting Enzyme Inhibitor–Based Regimens: An Individual Patient Data Meta-Analysis From Randomized, Placebo-Controlled Trials.
Field | Value | Language |
dc.contributor.author | Bell, Katy J.L. | |
dc.contributor.author | Hayen, Andrew | |
dc.contributor.author | Macaskill, Petra | |
dc.contributor.author | Craig, Jonathan C | |
dc.contributor.author | Neal, Bruce | |
dc.contributor.author | Fox, Kim M | |
dc.contributor.author | Remme, Willem J | |
dc.contributor.author | Asselbergs, Folkert W | |
dc.contributor.author | Van Gilst, Wiek H | |
dc.contributor.author | MacMahon, Stephen | |
dc.contributor.author | Remuzzi, Giuseppe | |
dc.contributor.author | Ruggenenti, Piero | |
dc.contributor.author | Teo, Koon K | |
dc.contributor.author | Irwig, Les | |
dc.date.accessioned | 2021-02-18T04:25:39Z | |
dc.date.available | 2021-02-18T04:25:39Z | |
dc.date.issued | 2010 | en_AU |
dc.identifier.uri | https://hdl.handle.net/2123/24535 | |
dc.description.abstract | Most clinicians monitor blood pressure to estimate a patient’s response to blood pressure–lowering therapy. However, the apparent change may not actually reflect the effect of the treatment, because a person’s blood pressure varies considerably even without the administration of drug therapy. We estimated random background within-person variation, apparent between-person variation, and true between-person variation in blood pressure response to angiotensin-converting enzyme inhibitors after 3 months. We used meta-analytic mixed models to analyze individual patient data from 28 281 participants in 7 randomized, controlled trials from the Blood Pressure Lowering Trialists Collaboration. The apparent between-person variation in response was large, with SDs for change in systolic blood pressure/diastolic blood pressure of 15.2/8.5 mm Hg. Within-person variation was also large, with SDs for change in systolic blood pressure/diastolic blood pressure of 14.9/8.45 mm Hg. The true between-person variation in response was small, with SDs for change in systolic blood pressure/diastolic blood pressure of 2.6/1.0 mm Hg. The proportion of the apparent between-person variation in response that was attributed to true between-person variation was only 3% for systolic blood pressure and 1% for diastolic blood pressure. In conclusion, most of the apparent variation in response is not because of true variation but is a consequence of background within-person fluctuation in day-to-day blood pressure levels. Instead of monitoring an individual’s blood pressure response, a better approach may be to simply assume the mean treatment effect. | en_AU |
dc.language.iso | en | en_AU |
dc.publisher | Publishing House Zaslavsky | en_AU |
dc.relation.ispartof | Hypertension | en_AU |
dc.rights | Creative Commons Attribution 4.0 | en_AU |
dc.subject | blood pressure | en_AU |
dc.subject | angiotensin-converting enzyme inhibitors | en_AU |
dc.subject | treatment outcome | en_AU |
dc.subject | models | en_AU |
dc.subject | reproducibility of results | en_AU |
dc.subject | stroke | en_AU |
dc.subject | statistical | en_AU |
dc.title | Monitoring Initial Response to Angiotensin-Converting Enzyme Inhibitor–Based Regimens: An Individual Patient Data Meta-Analysis From Randomized, Placebo-Controlled Trials. | en_AU |
dc.type | Article | en_AU |
dc.subject.asrc | 1102 Cardiorespiratory Medicine and Haematology | en_AU |
dc.subject.asrc | 1117 Public Health and Health Services | en_AU |
dc.identifier.doi | 10.1161/HYPERTENSIONAHA.110.152421 | |
dc.relation.nhmrc | 457212 | |
dc.relation.nhmrc | 402764 | |
dc.relation.nhmrc | 358395 | |
dc.relation.other | Servier | |
dc.relation.other | Health Research Council of New Zealand | |
dc.relation.other | Dutch Kidney Foundation | |
dc.relation.other | The Netherlands Heart Foundation | |
dc.relation.other | Bristol-Myers Squibb | |
dc.relation.other | Hoechst AG | |
dc.relation.other | Abbott GmbH & Co | |
dc.relation.other | Medical Research Council of Canada | |
dc.relation.other | Merck Frosst Canada Inc | |
usyd.faculty | SeS faculties schools::Faculty of Medicine and Health::Sydney School of Public Health | en_AU |
usyd.citation.volume | 56 | en_AU |
usyd.citation.issue | 3 | en_AU |
usyd.citation.spage | 533 | en_AU |
usyd.citation.epage | 539 | en_AU |
workflow.metadata.only | No | en_AU |
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