A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention

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Open Access

Field	Value	Language
dc.contributor.author	Oehlers, Stefan
dc.contributor.author	Hortle, Elinor
dc.contributor.author	Cook, Kristina
dc.date.accessioned	2020-06-24
dc.date.available	2020-06-24
dc.date.issued	2020-01-01	en_AU
dc.identifier.uri	https://hdl.handle.net/2123/22669
dc.description.abstract	Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild, Mohamed, and Wootton et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective Hif-1 activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies.	en_AU
dc.language.iso	en	en_AU
dc.publisher	The FEBS Journal	en_AU
dc.relation.ispartof	The FEBS Journal	en_AU
dc.rights	Copyright All Rights Reserved	en_AU
dc.title	A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention	en_AU
dc.type	Article	en_AU
dc.subject.asrc	11 Medical and Health Sciences	en_AU
dc.subject.asrc	1107 Immunology	en_AU
dc.subject.asrc	1108 Medical Microbiology	en_AU
dc.identifier.doi	10.1111/febs.15463
dc.relation.other	NSW Ministry of Health under the NSW Health Early-Mid Career Fellowships Scheme H18/31086
usyd.faculty	SeS faculties schools::Faculty of Medicine and Health	en_AU
workflow.metadata.only	No	en_AU