A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention

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Open Access

Field	Value	Language
dc.contributor.author	Oehlers, Stefan
dc.contributor.author	Hortle, Elinor
dc.contributor.author	Cook, Kristina
dc.date.accessioned	2020-06-24
dc.date.available	2020-06-24
dc.date.issued	2020-01-01	en
dc.identifier.uri	https://hdl.handle.net/2123/22669
dc.description.abstract	Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild, Mohamed, and Wootton et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective Hif-1 activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies.	en
dc.language.iso	en	en
dc.publisher	The FEBS Journal	en
dc.relation.ispartof	The FEBS Journal	en
dc.rights	Copyright All Rights Reserved	en
dc.title	A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention	en
dc.type	Article	en
dc.subject.asrc	11 Medical and Health Sciences	en
dc.subject.asrc	1107 Immunology	en
dc.subject.asrc	1108 Medical Microbiology	en
dc.identifier.doi	10.1111/febs.15463
dc.relation.other	NSW Ministry of Health under the NSW Health Early-Mid Career Fellowships Scheme H18/31086
usyd.faculty	SeS faculties schools::Faculty of Medicine and Health	en
workflow.metadata.only	No	en