A zebrafish model of tuberculosis comorbidity and the effects of HIF-activating intervention

Abstract

Comorbidities are an important factor in tuberculosis pathophysiology and treatment but are understudied in animal models. Schild, Mohamed, and Wootton et al. present a zebrafish model of Mycobacterium marinum infection and wound comorbidity that retains responsiveness to protective Hif-1 activation as an example of a host-directed therapy. This platform is a new paradigm for the zebrafish-M. marinum infection model and provides a blueprint to test therapeutic interventions on infection and comorbid pathologies.