School of Life and Environmental Sciences: Recent submissions

    • Potent Anti-SARS-CoV_2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L 

      Ashhurst, Anneliese S.; Tang, Arthur H.; Fajtova_, Pavla; Yoon, Michael C.; Aggarwal, Anupriya; Bedding, Max J.; Stoye, Alexander; Beretta, Laura; Pwee, Dustin; Drelich, Aleksandra; Skinner, Danielle; Li, Linfeng; Meek, Thomas D.; McKerrow, James H.; Hook, Vivian; Tseng, Chien-Te; Larance, Mark; Turville, Stuart; Gerwick, William H.; O’Donoghue, Anthony J.; Payne, Richard J.
      Published 2021
      Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a promising drug target for novel antivirals against SARS-CoV-2. The marine natural product gallinamide A and several synthetic ...
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    • Supercentenarians that Survived COVID-19. 

      Siopis, George
      Published 2021
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    • Total virome characterizations of game animals in China reveals a spectrum of emerging viral pathogens 

      He, Wan-Ting; Hou, Xin; Zhao, Jin; Sun, Jiumeng; He, Haijian; Si, Wei; Wang, Jing; Jiang, Zhiwen; Yan, Ziqing; Xing, Gang; Lu, Meng; Suchard, Marc A.; Ji, Xiang; Gong, Wenjie; He, Biao; Li, Jun; Lemey, Philippe; Guo, Deyin; Tu, Changchun; Holmes, Edward C.; Shi, Mang; Su, Shuo
      Published 2021
      Game animals are wildlife species often traded and consumed as exotic food, and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1725 game animals, representing 16 species ...
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    • Emergence and spread of SARS-CoV-2 lineages B.1.1.7 and P.1 in Italy 

      Di Giallonardo, Francesca; Puglia, Ilaria; Curini, Valentina; Cammà, Cesare; Mangone, Iolanda; Calistri, Paolo; Cobbin, Joanna C.A.; Holmes, Edward C.; Lorusso, Alessio
      Published 2021
      Italy’s second wave of SARS-CoV-2 has hit hard, with more than 3 million cases and over 100,000 deaths, representing an almost ten-fold increase on the numbers reported by August 2020. Herein, we present the analysis of ...
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    • The impact of public health interventions in the Nordic countries during the first year of SARS-CoV-2 transmission and evolution. 

      Duchene, Sebastian; Featherstone, Leo; Freiesleben de Blasio, Birgitte; Holmes, Edward C.; Bohlin, Jon; Pettersson, John H-O
      Published 2021
      BackgroundMany countries have attempted to mitigate and control COVID-19 through non-pharmaceutical interventions, particularly with the aim of reducing population movement and contact. However, it remains unclear how the ...
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