Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation- Desulfurization Chemistry

Malins, Lara R.; Giltrap, Andrew M.; Dowman, Luke J.; Payne, Richard J.

Access status:

Open Access

Field	Value	Language
dc.contributor.author	Malins, Lara R.
dc.contributor.author	Giltrap, Andrew M.
dc.contributor.author	Dowman, Luke J.
dc.contributor.author	Payne, Richard J.
dc.date.accessioned	2020-06-19
dc.date.available	2020-06-19
dc.date.issued	2015-04-10
dc.identifier.uri	https://hdl.handle.net/2123/22625
dc.description.abstract	The efficient synthesis of a β-thiol phenylalanine derivative is described starting from Garner’s aldehyde. The utility of this amino acid in peptide ligation–desulfurization chemistry is described, including the trifluoroethanethiol (TFET)-promoted one-pot assembly of the 62 residue peptide hormone augurin.	en
dc.language.iso	en_US	en
dc.publisher	American Chemical Society	en
dc.relation	ARC FT130100150	en
dc.rights	Other	en
dc.subject	Aldehydes	en
dc.subject	Peptides and proteins	en
dc.subject	Monomers	en
dc.subject	Chemical synthesis	en
dc.subject	Ligation	en
dc.title	Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation- Desulfurization Chemistry	en
dc.type	Article	en
dc.subject.asrc	FoR::030599 - Organic Chemistry not elsewhere classified	en
dc.identifier.doi	10.1021/acs.orglett.5b00597
dc.type.pubtype	Author accepted manuscript	en
dc.relation.arc	FT130100150
dc.rights.other	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.5b00597	en
usyd.faculty	SeS faculties schools::Faculty of Science	en