Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry

Access status:

Open Access

Field	Value	Language
dc.contributor.author	Thompson, Robert E.
dc.contributor.author	Liu, Xuyu
dc.contributor.author	Alonso-Garcia, Noelia
dc.contributor.author	Pereira, Pedro Jose Barbosa
dc.contributor.author	Jolliffe, Katrina A.
dc.contributor.author	Payne, Richard J.
dc.date.accessioned	2020-06-19
dc.date.available	2020-06-19
dc.date.issued	2014-05-15
dc.identifier.uri	https://hdl.handle.net/2123/22613
dc.description.abstract	Native chemical ligation followed by desulfurization is a powerful strategy for the assembly of proteins. Here we describe the development of a high-yielding, one-pot ligation−desulfurization protocol that uses trifluoroethanethiol (TFET) as a novel thiol additive. The synthetic utility of this TFET-enabled methodology is demonstrated by the efficient multi-step one-pot syntheses of two tick-derived proteins, chimadanin and madanin-1, without the need for any intermediary purification.	en
dc.language.iso	en_US	en
dc.publisher	American Chemical Society	en
dc.rights	Other	en
dc.subject	Additives	en
dc.subject	Thiols	en
dc.subject	Peptides and proteins	en
dc.subject	Monomers	en
dc.subject	Ligation	en
dc.title	Trifluoroethanethiol: An Additive for Efficient One-Pot Peptide Ligation−Desulfurization Chemistry	en
dc.type	Article	en
dc.subject.asrc	FoR::030599 - Organic Chemistry not elsewhere classified	en
dc.identifier.doi	10.1021/ja502806r
dc.type.pubtype	Author accepted manuscript	en
usyd.faculty	Faculty of Science	en