A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein

Field	Value	Language
dc.contributor.author	Zhou, Hong	en
dc.contributor.author	Chen, Xing	en
dc.contributor.author	Hu, Tao	en
dc.contributor.author	Li, Juan	en
dc.contributor.author	Song, Hao	en
dc.contributor.author	Liu, Yanran	en
dc.contributor.author	Wang, Peihan	en
dc.contributor.author	Liu, Di	en
dc.contributor.author	Yang, Jing	en
dc.contributor.author	Holmes, Edward C.	en
dc.contributor.author	Hughes, Alice C.	en
dc.contributor.author	Bi, Yuhai	en
dc.contributor.author	Shi, Weifeng	en
dc.date.accessioned	2020-06-18
dc.date.available	2020-06-18
dc.date.issued	2020	en
dc.identifier.uri	https://hdl.handle.net/2123/22563
dc.description.abstract	Metagenomic analysis identified a novel coronavirus, RmYN02, from R. malayanus. RmYN02 was the closest relative of SARS-CoV-2 in most of the virus genome. Two loop deletions in RBD may reduce the binding of RmYN02 with ACE2. RmYN02 contains an insertion at the S1/S2 cleavage site in the spike protein.	en
dc.language.iso	en	en
dc.rights	Other
dc.subject	COVID-19	en
dc.subject	Coronavirus	en
dc.title	A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein	en
dc.type	Article	en
dc.identifier.doi	10.1016/j.cub.2020.05.023
dc.relation.other	National Natural Science Foundation of China	en
dc.relation.other	Youth Innovation Promotion Association	en
dc.relation.other	Chinese Academy of Sciences	en
dc.relation.other	Australian Research Council	en
usyd.faculty	Faculty of Medicine and Health, Sydney Medical School	en

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