A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein
Type
ArticleAuthor/s
Zhou, HongChen, Xing
Hu, Tao
Li, Juan
Song, Hao
Liu, Yanran
Wang, Peihan
Liu, Di
Yang, Jing
Holmes, Edward C.
Hughes, Alice C.
Bi, Yuhai
Shi, Weifeng
Abstract
Metagenomic analysis identified a novel coronavirus, RmYN02, from R. malayanus. RmYN02 was the closest relative of SARS-CoV-2 in most of the virus genome. Two loop deletions in RBD may reduce the binding of RmYN02 with ACE2. RmYN02 contains an insertion at the S1/S2 cleavage site in the spike protein.Metagenomic analysis identified a novel coronavirus, RmYN02, from R. malayanus. RmYN02 was the closest relative of SARS-CoV-2 in most of the virus genome. Two loop deletions in RBD may reduce the binding of RmYN02 with ACE2. RmYN02 contains an insertion at the S1/S2 cleavage site in the spike protein.
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Date
2020Funding information
National Natural Science Foundation of China
Youth Innovation Promotion Association
Chinese Academy of Sciences
Australian Research Council
Licence
OtherFaculty/School
Faculty of Medicine and Health, Sydney Medical SchoolShare