Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis
| Field | Value | Language |
| dc.contributor.author | Yu, Mingfeng | |
| dc.contributor.author | Nagalingam, Gayathri | |
| dc.contributor.author | Ellis, Samantha | |
| dc.contributor.author | Martinez, Elena | |
| dc.contributor.author | Sintchenko, Vitali | |
| dc.contributor.author | Spain, Malcolm | |
| dc.contributor.author | Rutledge, Peter J | |
| dc.contributor.author | Todd, Matthew H | |
| dc.contributor.author | Triccas, James A. | |
| dc.date.accessioned | 2020-05-07 | |
| dc.date.available | 2020-05-07 | |
| dc.date.issued | 2016-05-23 | |
| dc.identifier.citation | Yu, M., Nagalingam, G., Ellis, S., Martinez, E., Sintchenko, V., Spain, M., Rutledge, P., Todd, M., Triccas, J. (2016). Nontoxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 59(12), 5917-5921 | en |
| dc.identifier.uri | https://hdl.handle.net/2123/22237 | |
| dc.description.abstract | Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against pathogenic myco-bacteria. These compounds inhibit intracellular growth of Mycobacterium tuberculosis, are non-toxic to human cell lines and are active against multidrug-resistant M. tuberculosis strains, indicating a distinct mode of action. These compounds warrant further appraisal as novel agents to control TB in humans. | en |
| dc.description.sponsorship | This work was supported by the National Health and Medical Research Council (NHMRC) Project APP1084266, the NHMRC Center of Research Excellence in Tuberculosis Control (APP1043225) and the University of Sydney Sydnovate Fund. We acknowledge the Centre for Drug Candidate Optimization, Monash University for the ADME studies | en |
| dc.language.iso | en_AU | en |
| dc.publisher | American Chemical Society | en |
| dc.relation | National Health and Medical Research Council (NHMRC) Project APP1084266,and NHMRC Center of Research Excellence in Tuberculosis Control (APP1043225) | en |
| dc.rights | Other | en |
| dc.subject | Tuberculosis, mycobacteria, structure activity relationship, cyclam, in vitro studies | en |
| dc.title | Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis | en |
| dc.type | Article | en |
| dc.subject.asrc | 030503 | en |
| dc.subject.asrc | 030207 | en |
| dc.subject.asrc | 030401 | en |
| dc.identifier.doi | 10.1021/acs.jmedchem.6b00432 | |
| dc.type.pubtype | Post-print | en |
| usyd.faculty | Faculty of Science | en |
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