The proximal origin of SARS-CoV-2

Field	Value	Language
dc.contributor.author	Andersen, Kristian G.	en
dc.contributor.author	Rambaut, Andrew	en
dc.contributor.author	Lipkin, W. Ian	en
dc.contributor.author	Holmes, Edward C.	en
dc.contributor.author	Garry, Robert F.	en
dc.date.accessioned	2020-05-04
dc.date.available	2020-05-04
dc.date.issued	2020	en
dc.identifier.uri	https://hdl.handle.net/2123/22189
dc.description.abstract	SARS-CoV-2 is the seventh coronavirus known to infect humans; SARS-CoV, MERS-CoV and SARS-CoV-2 can cause severe disease, whereas HKU1, NL63, OC43 and 229E are associated with mild symptoms6. Here we review what can be deduced about the origin of SARS-CoV-2 from comparative analysis of genomic data. We offer a perspective on the notable features of the SARS-CoV-2 genome and discuss scenarios by which they could have arisen. Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus	en
dc.language.iso	en	en
dc.rights	Other
dc.subject	COVID-19	en
dc.subject	Coronavirus	en
dc.title	The proximal origin of SARS-CoV-2	en
dc.type	Article	en
dc.identifier.doi	10.1038/s41591-020-0820-9
dc.relation.other	National Institute of Allergy and Infectious Diseases	en
dc.relation.other	European Research Council	en
dc.relation.other	National Human Genome Research Institute	en
dc.relation.other	Australian Research Council	en
dc.relation.other	Wellcome Trust	en
usyd.faculty	Faculty of Science

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