Total Synthesis of Glycinocins A−C

Corcilius, Leo; Elias, Nabiha T.; Ochoa, Jessica L.; Linington, Roger G.; Payne, Richard J.

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Open Access

Field	Value	Language
dc.contributor.author	Corcilius, Leo
dc.contributor.author	Elias, Nabiha T.
dc.contributor.author	Ochoa, Jessica L.
dc.contributor.author	Linington, Roger G.
dc.contributor.author	Payne, Richard J.
dc.date.accessioned	2020-04-24
dc.date.available	2020-04-24
dc.date.issued	2017-09-15
dc.identifier.citation	Leo Corcilius, Nabiha T. Elias, Jessica L. Ochoa, Roger G. Linington, and Richard J. Payne , Total Synthesis of Glycinocins A−C, The Journal of Organic Chemistry 2017 82 (23), 12778-12785 DOI: 10.1021/acs.joc.7b01959	en
dc.identifier.uri	https://hdl.handle.net/2123/22107
dc.description.abstract	The glycinocins are a class of calcium-dependent, acidic cyclolipopeptide antibiotics structurally related to the clinically approved daptomycin. Herein, we describe a divergent total synthesis of glycinocins A–C, which differ in the structure of a branched α,β-unsaturated fatty acyl moiety. The three natural products exhibited calcium-dependent antimicrobial activity against Staphylococcus aureus and Bacillus subtilis with MICs ranging from 5.5 to 17 μM.	en
dc.description.sponsorship	ARC	en
dc.language.iso	en_US	en
dc.publisher	American Chemical Society	en
dc.relation	ARC FT130100150	en
dc.rights	Other	en
dc.subject	Lipids	en
dc.subject	Peptides and proteins	en
dc.subject	antimicrobial activity	en
dc.subject	Pharmaceuticals	en
dc.subject	Bacteria	en
dc.title	Total Synthesis of Glycinocins A−C	en
dc.type	Article	en
dc.subject.asrc	FoR::030599 - Organic Chemistry not elsewhere classified	en
dc.subject.asrc	FoR::030499 - Medicinal and Biomolecular Chemistry not elsewhere classified	en
dc.subject.asrc	FoR::030502 - Natural Products Chemistry	en
dc.identifier.doi	10.1021/acs.joc.7b01959
dc.type.pubtype	Author accepted manuscript	en
dc.relation.arc	FT130100150
usyd.faculty	SeS faculties schools::Faculty of Science	en