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dc.contributor.authorJohansen, Matt
dc.contributor.authorKasparian, Joshua
dc.contributor.authorHortle, Elinor
dc.contributor.authorBritton, Warwick
dc.contributor.authorPurdie, Auriol
dc.contributor.authorOehlers, Stefan
dc.date.accessioned2020-02-12T04:33:31Z
dc.date.available2020-02-12T04:33:31Z
dc.date.issued2018-11
dc.identifier.citation88:169-172en_AU
dc.identifier.urihttps://hdl.handle.net/2123/21835
dc.description.abstractHost lipid metabolism is an important target for subversion by pathogenic mycobacteria such as Mycobacterium tuberculosis. The appearance of foam cells within the granuloma are well-characterised effects of chronic tuberculosis. The zebrafish-Mycobacterium marinum infection model recapitulates many aspects of human-M. tuberculosis infection and is used as a model to investigate the structural components of the mycobacterial granuloma. Here, we demonstrate that the zebrafish-M. marinum granuloma contains foam cells and that the transdifferentiation of macrophages into foam cells is driven by the mycobacterial ESX1 pathogenicity locus. This report demonstrates conservation of an important aspect of mycobacterial infection across species.en_AU
dc.description.sponsorshipThis work was supported by the Australian National Health and Medical Research Council (APP1099912 and APP1053407 to S.H.O.); Meat and Livestock Australia (P.PSH. 0813 to A.C.P.); the Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney (grant to S.H.O. and A.C.P.); University of Sydney Fellowship (grant to S.H.O.); and the Kenyon Family Inflammation Award (grant to S.H.O.).en_AU
dc.language.isoenen_AU
dc.publisherDevelopmental & Comparative Immunologyen_AU
dc.relationNHMRC APP1053407 and APP1099912en_AU
dc.subjectFoam cell; Granuloma; Lipid; Mycobacterium; Pathogenesis; Zebrafishen_AU
dc.titleMycobacterium marinum infection drives foam cell differentiation in zebrafish infection modelsen_AU
dc.typeArticleen_AU
dc.subject.asrcFoR::110707 - Innate Immunityen_AU
dc.subject.asrcFoR::110801 - Medical Bacteriologyen_AU
dc.identifier.doi10.1016/j.dci.2018.07.022
dc.type.pubtypePost-printen_AU


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