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dc.contributor.authorLambropoulos, Nicholas
dc.contributor.authorGarcia, Alvaro
dc.contributor.authorClarke, Ronald J.
dc.date.accessioned2019-09-10
dc.date.available2019-09-10
dc.date.issued2015-12-29
dc.identifier.citationLambropoulos, N., Garcia, A., & Clarke, R. J. (2015). Stimulation of Na+,K+-ATPase Activity as a Possible Driving Force in Cholesterol Evolution. The Journal of Membrane Biology, 249(3), 251–259. https://doi.org/10.1007/s00232-015-9864-zen_AU
dc.identifier.urihttp://hdl.handle.net/2123/21064
dc.description.abstractCholesterol is exclusively produced by animals and is present in the plasma membrane of all animal cells. In contrast, the membranes of fungi and plants contain other sterols. To explain the exclusive preference of animal cells for cholesterol we propose that cholesterol may have evolved to optimise the activity of a crucial protein found in the plasma membrane of all multicellular animals, namely the Na+,K+-ATPase. To test this hypothesis mirror tree and phylogenetic distribution analyses have been conducted of the Na+,K+-ATPase and 3β-hydroxysterol Δ24-reductase (DHCR24), the last enzyme in the Bloch cholesterol biosynthetic pathway. The results obtained support the hypothesis of a co-evolution of the Na+,K+-ATPase and DHCR24. The evolutionary correlation between DHCR24 and the Na+,K+-ATPase was found to be stronger than between DHCR24 and any other membrane protein investigated. The results obtained, thus, also support the hypothesis that cholesterol evolved together with the Na+,K+-ATPase in multicellular animals to support Na+,K+-ATPase activity.en_AU
dc.description.sponsorshipAustralian Research Councilen_AU
dc.language.isoen_AUen_AU
dc.publisherSpringeren_AU
dc.relationARC DP121003548, ARC DP150101112en_AU
dc.rightsThis is a post-peer-review, pre-copyedit version of an article published in The Journal of Membrane Biology. The final authenticated version is available online at: doi 10.1007/s00232-015-9864-z.en_AU
dc.subjectsodium pumpen_AU
dc.subjectplasma membraneen_AU
dc.subject3beta-hydroxysterol Delta24-reductaseen_AU
dc.subjectsqualene monooxygenaseen_AU
dc.subjectmirror tree analysisen_AU
dc.titleStimulation of Na+,K+-ATPase activity as a possible driving foce in cholesterol evolutionen_AU
dc.typeArticleen_AU
dc.subject.asrcFoR::030403 - Characterisation of Biological Macromoleculesen_AU
dc.identifier.doidoi 10.1007/s00232-015-9864-z
dc.type.pubtypePost-printen_AU


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