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dc.contributor.authorVleeskens, Elizabeth
dc.contributor.authorClarke, Ronald J.
dc.date.accessioned2019-09-09
dc.date.available2019-09-09
dc.date.issued2018-03-01
dc.identifier.citationVleeskens, E., & Clarke, R. J. (2018). Kinetic contribution to extracellular Na+ /K+ selectivity in the Na+ /K+ pump. FEBS Open Bio, 8(5), 854–859. https://doi.org/10.1002/2211-5463.12418en_AU
dc.identifier.urihttp://hdl.handle.net/2123/21046
dc.description.abstractThe sodium potassium pump (Na+,K+-ATPase) shows a high selectivity for K+ over Na+ binding from the extracellular medium. To understand the K+ selectivity in the presence of a high concentration of competing Na+ ions requires consideration of more than just ion binding affinities. Here, equilibrium-based calculations of the extracellular occupation of the Na+,K+-ATPase transport sites by Na+ and K+ are compared to fluxes through Na+ and K+ transport pathways. The results show that, under physiological conditions, there is a 332 fold selectivity for pumping of K+ from the extracellular medium into the cytoplasm relative to Na+, whereas equilibrium calculations alone predict only a 7.5 fold selectivity for K+. Thus, kinetic effects make a major contribution to the determination of extracellular K+ selectivity.en_AU
dc.description.sponsorshipAustralian Research Councilen_AU
dc.language.isoen_AUen_AU
dc.publisherWileyen_AU
dc.relationARC DP121003548, ARC DP150101112, ARC DP170101732en_AU
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_AU
dc.subjection selectivityen_AU
dc.subjectkinetic modellingen_AU
dc.subjectNa+,K+-ATPaseen_AU
dc.titleKinetic contribution to extracellular Na+/K+ selectivity in the Na+/K+ pumpen_AU
dc.typeArticle, Letteren_AU
dc.subject.asrcFoR::030403 - Characterisation of Biological Macromoleculesen_AU
dc.identifier.doidoi:10.1002/2211-5463.12418
dc.type.pubtypePublisher versionen_AU


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