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dc.contributor.authorLu, Shen
dc.contributor.authorXia, Yong
dc.contributor.authorCai, Weidong
dc.contributor.authorFulham, Michael
dc.contributor.authorFeng, Dagan
dc.contributor.authorADNI
dc.date.accessioned2019-06-11
dc.date.available2019-06-11
dc.date.issued2017-02-07
dc.identifier.citationS. Lu, Y. Xia, W. Cai, D. Feng, M. Fulham, “Early identification of mild cognitive impairment using incomplete random forest-robust support vector machine and FDG-PET imaging”, Computerized Medical Imaging and Graphics, 60:35-41, September 2017.en_AU
dc.identifier.issn0895-6111
dc.identifier.urihttp://hdl.handle.net/2123/20528
dc.description.abstractAlzheimer’s disease (AD) is the most common type of dementia and will be an increasing health problem in society as the population ages. Mild cognitive impairment (MCI) is considered to be a prodromal stage of AD. The ability to identify subjects with MCI will be increasingly important as disease modifying therapies for AD are developed. We propose a semi-supervised learning method based on robust optimization for the identification of MCI from [18F]Fluorodeoxyglucose PET scans. We extracted three groups of spatial features from the cortical and subcortical regions of each FDG-PET image volume. We measured the statistical uncertainty related to these spatial features via transformation using an incomplete random forest and formulated the MCI identification problem under a robust optimization framework. We compared our approach to other state-of-the-art methods in different learning schemas. Our method outperformed the other techniques in the ability to separate MCI from normal controls.en_AU
dc.publisherElsevieren_AU
dc.relationARC DP140100211
dc.rightsThe final authenticated version is available online at: https://doi.org/10.1016/j.compmedimag.2017.01.001 with CC-BY-NC-ND licenseen_AU
dc.subjectFDG-PET, Alzheimer’s disease, Mild cognitive impairment, Robust optimizationen_AU
dc.titleEarly identification of mild cognitive impairment using incomplete random forest-robust support vector machine and FDG-PET imagingen_AU
dc.typeArticleen_AU
dc.identifier.doihttps://doi.org/10.1016/j.compmedimag.2017.01.001
dc.type.pubtypePost-printen_AU


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