• Development of a library of thiophene-based drug-like LEGO molecules: evaluation of their anion binding, transport properties and cytotoxicity 

      Vieira, Paulo; Miranda, Margarida Q.; Marques, Igor; Carvalho, Sílvia; Li-Jun, Chen; Howe, Ethan N.W.; Zhen, Carl; Leung, Claudia Y.; Spooner, Michael J.; Morgado, Bárbara; da Cruz e Silva, Odete A.B.; Moiteiro, Cristina; Gale, Philip A.; Félix, Vítor
      Published 2020-01-01
      The anion binding and transport properties of an extensive library of thiophene-based molecules are reported. Seventeen bis-urea positional isomers, with different binding conformations and lipophilicities, were synthetized ...
      Open Access
      Article
    • Design of Chiral Supramolecular Polymers Exhibiting a Negative Nonlinear Response 

      Chen, Xuan-Xuan; Lin, Xiao-Yan; Wu, Xin; Gale, Philip A.; Anslyn, Eric V.; Jiang, Yun-Bao
      Published 2019-01-01
      Many synthetic and supramolecular chiral polymeric systems are known to exhibit the “majority rules effect” (MRE), a positive nonlinear response in which a small enantiomeric excess (ee) of the chiral building blocks leads ...
      Open Access
      Article
    • Advances in Anion Receptor Chemistry 

      Chen, Lijun; Berry, Stuart N.; Wu, Xin; Howe, Ethan N.W.; Gale, Philip A.
      Published 2020-01-01
      This review covers advances in anion complexation in the years 2017 and 2018. The review focuses on the applications of anion receptor chemistry, including sensing, self-assembly, extraction, transport, catalysis, and ...
      Open Access
      Article
    • Selective anion transport mediated by strap-extended calixpyrroles 

      Clarke, Harriet J.; Wu, Xin; Light, Mark E.; Gale, Philip A.
      Published 2020-01-01
      Synthetic anion receptors that facilitate transmembrane chloride transport are of interest as potential therapeutic agents for cancer and cystic fibrosis. Transporters selective for chloride over protons are desired for ...
      Open Access
      Article
    • Stimuli-responsive cycloaurated ‘OFF-ON’ switchable anion transporters 

      Fares, Mohamed; Wu, Xin; Ramesh, Deepthi; Lewis, William; Keller, Paul A.; Howe, Ethan N.W.; Pérez-Tomás, Ricardo; Gale, Philip A.
      Published 2020-01-01
      Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes ...
      Open Access
      Article