Browsing Faculty of Science by subject "030503"
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Anti-Tubercular bis-Substituted Cyclam Derivatives: Structure-Activity Relationships and In Vivo Studies
Published 2018-03-20We recently reported the discovery of non-toxic cyclam-derived compounds that are active against drug-resistant Mycobacterium tuberculosis. In this paper we report exploration of the structure-activity relationship for ...Open AccessArticle -
Cyclobutanone analogues of beta‐lactam antibiotics: beta‐lactamase inhibitors with untapped potential?
Published 2016-12-19Beta‐Lactam antibiotics have been used for many years to treat bacterial infections. However the effective treatment of an increasing range of microbial infections is threatened by bacterial ...Open AccessArticle -
Electronic Lab Notebook for Synthesis of Tuberculosis Drug Leads
Published 2013-01-01A snapshot of an electronic laboratory notebook used to record the synthesis of new small molecules intended for the treatment of tuberculosis. The compounds are synthesised using an oxa-Pictet Spengler reaction, and are ...Open AccessDataset -
NMR Data for Synthesis of Spiro Tuberculosis Drug Leads
Published 2014-05-14NMR data supporting Electronic Lab Notebook for Synthesis of Tuberculosis Drug Leads (http://hdl.handle.net/2123/10461), specifically the paper published based on this work. The NMR spectra/data are for the chemical compounds ...Open AccessDataset -
Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis
Published 2016-05-23Tuberculosis (TB) accounted for 1.5 million deaths in 2014 and new classes of anti-TB drugs are required. We re-port a class of functionalized 1,8-disubstituted cyclam derivatives that display low micromolar activity against ...Open AccessArticle -
Selective sensing of pyrophosphate in physiological media using zinc(II)dipicolylamino-functionalised peptides
Published 2015-01-01A series of linear peptide based anion receptors, in which the distance between the bis[zinc(II)dipicolylamine] binding sites and the peptide backbone was varied systematically, was prepared and their anion binding ability ...Open AccessArticle