Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii)
Access status:
Open Access
Type
ArticleAbstract
The Tasmanian devil is an endangered marsupial species that has survived several historical bottlenecks and now has low genetic diversity. Here we characterize the Toll-like receptor (TLR) genes and their diversity in the Tasmanian devil. TLRs are a key innate immune gene family ...
See moreThe Tasmanian devil is an endangered marsupial species that has survived several historical bottlenecks and now has low genetic diversity. Here we characterize the Toll-like receptor (TLR) genes and their diversity in the Tasmanian devil. TLRs are a key innate immune gene family found in all animals. Ten TLR genes were identified in the Tasmanian devil genome. Unusually low levels of diversity were found in 25 devils from across Tasmania. We found two alleles at TLR2, TLR3 and TLR6. The other seven genes were monomorphic. The insurance population, which safeguards the species from extinction, has successfully managed to capture all of these TLR alleles, but concerns remain for the long-term survival of this species.
See less
See moreThe Tasmanian devil is an endangered marsupial species that has survived several historical bottlenecks and now has low genetic diversity. Here we characterize the Toll-like receptor (TLR) genes and their diversity in the Tasmanian devil. TLRs are a key innate immune gene family found in all animals. Ten TLR genes were identified in the Tasmanian devil genome. Unusually low levels of diversity were found in 25 devils from across Tasmania. We found two alleles at TLR2, TLR3 and TLR6. The other seven genes were monomorphic. The insurance population, which safeguards the species from extinction, has successfully managed to capture all of these TLR alleles, but concerns remain for the long-term survival of this species.
See less
Date
2015-01-07Publisher
Springer-Verlag Berlin Heidelberg 2015Licence
“This is a post-peer-review, pre-copyedit version of an article published in Immunogenetics. The final authenticated version is available online at: DOI 10.1007/s00251-014-0823-0"Citation
Cui, J., Cheng, Y., and Belov, K. (2015). "Diversity in the Toll-like receptor genes of the Tasmanian devil (Sarcophilus harrisii)." Immunogenetics 67(3): 195-201.Share