Discipline of Pharmacology: Recent submissions
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Themed Section: Opioids New Pathways to Functional Selectivity
Published 2015-01-01"LINKED ARTICLES This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2"Open AccessArticle -
Chronic morphine reduces surface expression of δ-opioid receptors in subregions of rostral striatum
Published 2015-04-13The delta opioid receptor (DOPr), whilst not the primary target of clinically used opioids, is involved in development of opioid tolerance and addiction. There is growing evidence that DOPr trafficking is involved in drug ...Open AccessArticle -
β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons
Published 2015-01-01BACKGROUND AND PURPOSE: Tolerance to the behavioural effects of morphine is blunted in β-arrestin-2 knockout mice, but opioid withdrawal is largely unaffected. The cellular mechanisms of tolerance have been studied in some ...Open AccessArticle -
Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter
Published 2013-09-24Loopy peptides: Peptide turn mimetics of a clinically relevant norepinephrine reuptake inhibitor were developed employing a high-throughput synthesis approach to generate peptide thioesters, with subsequent cyclization ...Open AccessArticle -
Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model
Published 2013-09-01"BACKGROUND AND PURPOSE: Antagonists of the N-type voltage gated calcium channel (VGCC), Cav 2.2, have a potentially important role in the treatment of chronic neuropathic pain. ω-conotoxins, such MVIIA and CVID are effective ...Open AccessArticle