Browsing Discipline of Pharmacology by title
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2-methyl-4-chlorophenoxyacetic acid and bromoxynil herbicide death.
Published 2015-04-15CASE REPORT: We report a fatal case of a 37 year old gentleman who ingested a MCPA/bromoxynil co-formulation herbicide. Although clinically well on initial examination, our patient declined dramatically over his 18 h ...Open AccessArticle -
Acute alcohol co-ingestion and hospital-treated deliberate self-poisoning; is there an effect on subsequent self-harm?
Published 2018-03-01The aim of this study was to determine the relationship between alcohol co-ingestion in an index deliberate self-poisoning (DSP) episode with repeated DSP and subsequent suicide. A retrospective cohort study was conducted ...Open AccessArticle -
Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult.
Published 2015-09-01In a series of neurophysiological and neuroimaging studies we investigated the neurobiology related to alcohol use in young people with bipolar disorder. Impairments were identified across frontal and temporal representations ...Open AccessArticle -
Bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) poisoning could be a bad combination
Published 2018-01-30Open AccessArticle, Letter -
Challenges for Opioid Receptor Nomenclature
Published 2015-01-01Recent developments in the study of the structure and function of opioid receptors raise significant challenges for the definition of individual receptor types and the development of a nomenclature that precisely describes ...Open AccessArticle -
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
Published 2012-06-01The human neuroblastoma cell line SH-SY5Y is a potentially useful model for the identification and characterisation of Na(v) modulators, but little is known about the pharmacology of their endogenously expressed Na(v)s. ...Open AccessArticle -
Chronic morphine reduces surface expression of δ-opioid receptors in subregions of rostral striatum
Published 2015-04-13The delta opioid receptor (DOPr), whilst not the primary target of clinically used opioids, is involved in development of opioid tolerance and addiction. There is growing evidence that DOPr trafficking is involved in drug ...Open AccessArticle -
Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming
Published 2016-12-02BACKGROUND: Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This ...Open AccessArticle -
Clinical and Pharmacological Investigation of Myotoxicity in Sri Lankan Russell's Viper (Daboia russelii) Envenoming.
Published 2016-12-02BACKGROUND: Sri Lankan Russell's viper (Daboia russelii) envenoming is reported to cause myotoxicity and neurotoxicity, which are different to the effects of envenoming by most other populations of Russell's vipers. This ...Open AccessArticle -
Co-ingested alcohol and the timing of deliberate self-poisonings
Published 2018-08-01Objective: Investigating diurnal variation in the timing of suicidal behaviours offers opportunity to better understand its various proximal risk factors. Acute use of alcohol is a potent proximal risk factor for suicidal ...Open AccessArticle -
A Continuous, Fluorescence-based Assay of µ-Opioid Receptor Activation in AtT-20 Cells
Published 2013-03-01Opioids are widely prescribed analgesics, but their use is limited due to development of tolerance and addiction, as well as high variability in individual response. The development of improved opioid analgesics requires ...Open AccessArticle -
A decade of Australian methotrexate dosing errors
Published 2016-06-06"OBJECTIVE: Accidental daily dosing of methotrexate can result in life-threatening toxicity. We investigated methotrexate dosing errors reported to the National Coronial Information System (NCIS), the Therapeutic Goods ...Open AccessArticle -
Dexamethasone Modifies Cystatin C-Based Diagnosis of Acute Kidney Injury During Cisplatin-Based Chemotherapy
Published 2017-03-17BACKGROUND/AIMS: Plasma cystatin C (pCysC) may be superior to serum creatinine (sCr) as a surrogate of GFR. However, the performance of pCysC for diagnosing acute kidney injury (AKI) after cisplatin-based chemotherapy is ...Open AccessArticle -
Diagnosis-based and external cause-based criteria to identify adverse drug reactions in hospital ICD-coded data: application to an Australia population-based study
Published 2017-04-27OBJECTIVES: External cause International Classification of Diseases (ICD) codes are commonly used to ascertain adverse drug reactions (ADRs) related to hospitalisation. We quantified ascertainment of ADR-related hospitalisation ...Open AccessArticle -
Discontinuities and disruptions in drug dosage guidelines for the paediatric population
Published 2018-02-07AIMSThis study investigates paediatric drug dosage guidelines withthe aim of investigating their agreement with body surface area(BSA) scaling principles.METHODSA total of 454 drug dosage guidelines listed in the AMH-CDC ...Open AccessArticle -
Effects of 8 weeks of CPAP on lipid-based oxidative markers in obstructive sleep apnea: a randomized trial
Published 2014-12-22Dyslipidaemia and increased oxidative stress have been reported in severe obstructive sleep apnea, and both may be related to the development of cardiovascular disease. We have previously shown in a randomized crossover ...Open AccessArticle -
Fuel poverty increases risk of mould contamination, regardless of adult risk perception & ventilation in social housing properties
Published 2015-06-01INTRODUCTION: Fuel poverty affects 2.4 million UK homes leading to poor hygrothermal conditions and risk of mould and house dust mite contaminations, which in turn increases risk of asthma exacerbation. For the first time ...Open AccessArticle -
Functional Analysis of Novel Polymorphisms in the Human SLCO1A2 Gene that Encodes the Transporter OATP1A2
Published 2013-08-06The solute carrier organic anion transporting polypeptide 1A2 (OATP1A2, SLCO1A2) is implicated in the cellular influx of a number of drugs. We identified five novel single nucleotide polymorphisms (SNPs) in coding exons ...Open AccessArticle -
Glutamate transporter dysfunction associated with nerve injury-induced pain in mice
Published 2012-01-01Dysfunction at glutamatergic synapses has been proposed as a mechanism in the development of neuropathic pain. Here we sought to determine whether peripheral nerve injury-induced neuropathic pain results in functional ...Open AccessArticle -
Glycine transport inhibitors for the treatment of pain.
Published 2014-08-01Opioids, local anesthetics, anticonvulsant drugs, antidepressants, and non-steroidal anti-inflammatory drugs (NSAIDs) are used to provide pain relief but they do not provide adequate pain relief in a large proportion of ...Open AccessArticle