Discipline of Pharmacology: Recent submissions
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Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons
Published 2012-03-01Agonists acting on µ-opioid receptors (MOR) are very effective analgesics but cause tolerance during long-term or repeated exposure. Intensive efforts have been made to find novel opioid agonists that are efficacious ...Open AccessArticle -
Plasticity in striatopallidal projection neurons mediates the acquisition of habitual actions
Published 2015-08-01In instrumental conditioning, newly acquired actions are generally goal-directed and are mediated by the relationship between the action and its consequences or outcome. With continued training, however, the performance ...Open AccessArticle -
Challenges for Opioid Receptor Nomenclature
Published 2015-01-01Recent developments in the study of the structure and function of opioid receptors raise significant challenges for the definition of individual receptor types and the development of a nomenclature that precisely describes ...Open AccessArticle -
Characterisation of Nav types endogenously expressed in human SH-SY5Y neuroblastoma cells
Published 2012-06-01The human neuroblastoma cell line SH-SY5Y is a potentially useful model for the identification and characterisation of Na(v) modulators, but little is known about the pharmacology of their endogenously expressed Na(v)s. ...Open AccessArticle -
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain
Published 2012-06-01The large diversity of peptides from venomous creatures with high affinity for molecules involved in the development and maintenance of neuropathic pain has led to a surge in venom-derived analgesic research. Some members ...Open AccessArticle