NHMRC Clinical Trials Centre: Recent submissions

    • Quality of life among caregivers of people with end-stage kidney disease managed with dialysis or comprehensive conservative care 

      Shah, Karan K.; Murtagh, Fliss E.M.; McGeechan, Kevin; Crail, Susan M.; Burns, Aine; Morton, Rachael L.
      Published 2020
      Background: To measure health-related and care-related quality of life among informal caregivers of older people with end-stage kidney disease (ESKD), and to determine the association between caregiver quality of life and ...
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    • Identifying challenges to implementation of clinical practice guidelines for sentinel lymph node biopsy in patients with melanoma in Australia: protocol paper for a mixed methods study 

      Rapport, Frances; Smith, Andrea L.; Cust, Anne E.; Mann, Graham J.; Watts, Caroline G.; Gyorki, David E.; Henderson, Michael; Hong, Angela M.; Kelly, John W.; Long, Georgina V.; Mar, Victoria J.; Morton, Rachael L.; Saw, Robyn P.M.; Scolyer, Richard A.; Spillane, Andrew J.; Thompson, John F.; Braithwaite, Jeffrey
      Published 2020
      Introduction Sentinel lymph node biopsy (SLNB) is a diagnostic procedure developed in the 1990s. It is currently used to stage patients with primary cutaneous melanoma, provide prognostic information and guide management. ...
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    • When to replicate systematic reviews of interventions: consensus checklist 

      Tugwell, Peter; Welch, Vivian Andrea; Karunananthan, Sathya; Maxwell, Lara J.; Akl, Elie A.; Avey, Marc T.; Bhutta, Zulfiqar A.; Brouwers, Melissa C.; Clark, Jocalyn P.; Cook, Sophie; Cuervo, Luis Gabriel; Curran, Janet Agnes; Ghogomu, Elizabeth Tanjong; Graham, Ian G.; Grimshaw, Jeremy M.; Hutton, Brian; Loannidis, John P.A.; Jordan, Zoe; Jull, Janet Elizabeth; Kristjansson, Elizabeth; Langlois, Etienne V.; Little, Julian; Lyddiatt, Anne; Martin, Janet E.; Marušić, Ana; Mbuagbaw, Lawrence; Moher, David; Morton, Rachael L.; Nasser, Mona; Page, Matthew J.; Pardo Pardo, Jordi; Jennifer, Petkovic; Petticrew, Mark; Pigott, Terri; Pottie, Kevin; Rada, Gabriel; Rader, Tamara; Riddle, Alison; Rothstein, Hannah; Schüneman, Holger; Shamseer, Larissa; Shea, Beverley J.; Simeon, Rosiane; Siontis, Konstantinos C.; Smith, Maureen; Soares-Weiser, Karla; Thavorn, Kednapa; Thavorn, David Tovey; Vachon, Brigitte; Valentine, Jeffery; Villemaire, Rebecca; Walker, Peter; Weeks, Laura; Wells, George; Wilson, David B.; White, Howard
      Published 2020
      For systematic reviews of interventions, replication is defined as the reproduction of findings of previous systematic reviews looking at the same effectiveness question either by: purposefully repeating the same methods ...
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    • Cost-effectiveness analysis of PET/CT surveillance imaging to detect systemic recurrence in resected stage III melanoma: study protocol 

      Dieng, Mbathio; Khanna, Nikita; Nguyen, Mai Thi Hoang; Turner, Robin; Lord, Sarah J.; Menzies, Alexander M.; Allen, Jay; Saw, Robyn; Nieweg, Omgo E.; Thompson, John; Morton, Rachael L.
      Published 2020
      Introduction In the new era of effective systemic therapies for advanced melanoma, early detection of lower volume recurrent disease using surveillance imaging can improve survival. However, intensive imaging follow-up ...
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    • Feasibility and acceptability of ePROMs data capture and feedback among patients receiving haemodialysis in the Symptom monitoring WIth Feedback Trial (SWIFT) pilot: protocol for a qualitative study in Australia 

      Duncanson, Emily; Bennett, Paul N.; Viecelli, Andrea; Dansie, Kathryn; Handke, William; Tong, Allison; Palmer, Suetonia; Jesudason, Shilpanjali; McDonald, Stephen P.; Morton, Rachael L.
      Published 2020
      Introduction People receiving haemodialysis experience a high symptom burden and impaired quality of life. The use of patient-reported outcome measures (PROMs) is increasing in nephrology care, however their acceptability, ...
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