Browsing by author "Morrison, Daniel E."
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Efficient radiosynthesis of a [18F]-phosphonium salt containing closo-carborane
Ioppolo, Joseph A.; Giboureau, Nicolas; Bhadbhade, Mohan; Morrison, Daniel E.; Kassiou, Michael; Rendina, Louis M.Published 2017-11-15An efficient synthesis of an 18F-labelled phosphonium salt containing closo-carborane is described. The preparation of this salt was attempted using both single-step and two-step protocols, with greater success found for ...Open AccessArticle -
High mitochondrial accumulation of new gadolinium(III) agents within tumour cells
Morrison, Daniel E.; Aitken, Jade B.; de Jonge, Martin D.; Ioppolo, Joseph A.; Harris, Hugh H.; Rendina, Louis M.Published 2014-01-01The first bifunctional Gd(III) complexes covalently bound to arylphosphonium cations and the first tumour-cell selective mitochondrial agents designed for potential application in binary cancer therapies are reported. The ...Open AccessArticle -
Synthesis and biological evaluation of a class of mitochondrially-targeted gadolinium(III) agents
Morrison, Daniel E.; Aitken, Jade B.; de Jonge, Martin D.; Issa, Fatiah; Harris, Hugh H.; Rendina, Louis M.Published 2014-10-16A structure–activity relationship study of a library of novel bifunctional GdIII complexes covalently linked to arylphosphonium cations is reported. Such complexes have been designed for potential application in binary ...Open AccessArticle -
Tumor cell uptake and selectivity of gadolinium(III)-phosphonium complexes: The role of delocalisation at the phosphonium centre
Busse, Madleen; Windsor, Madeline S. A.; Tefay, Alexander J.; Kardashinsky, Mingyue; Fenton, Jacob M.; Morrison, Daniel E.; Harris, Hugh H.; Rendina, Louis M.Published 2017-12-01The synthesis of a series of bifunctional Gd(III) complexes 1–3 covalently bound to arylphosphonium cations possessing a varying degree of delocalisation at the phosphonium centre is presented. The influence of the degree ...Open AccessArticle
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