Sydney Digital Theses (University of Sydney Access only): Recent submissions
-
Toll like receptor 2 mediated alpha synuclein pathology in Parkinsons disease
Published 2023α-Synuclein (αSyn) plays a critical role in the pathogenesis of Parkinson's disease (PD). Initially, it was thought to exist exclusively within cells. However, evidence suggests its presence in cerebrospinal fluid, plasma, ...USyd AccessThesis -
Monocyte Functional and Metabolic Re-Programming Induced by Oxidized LDL
Published 2024Background: Dyslipidaemia affects 2 in 3 adult Australians and increases the lifetime risk of atherosclerotic cardiovascular diseases (ASCVDs). The stability of atherosclerotic lesions is associated with macrophage phenotype, ...USyd AccessThesis -
Improving Health Services Delivery for Better Outcomes for Aboriginal and Torres Strait Islander Children
Published 2024Objectives: To identify and describe the outcomes of health services for Aboriginal and Torres Strait Islander children valued by stakeholders, and to elicit the preferences of stakeholders for characteristics of health ...USyd AccessThesis -
Application of Novel Proteomic Methods to B Cells and the B Cell Receptor
Published 2024B cells are an integral part of the adaptive immune response with expression of surface immunoglobulin in a B cell receptor (BCR) complex. BCR engagement with antigen results in activation of B cells to eliminate targeted ...USyd AccessThesis -
Assessing the Biomarker Potential of LRRK2, GCase and Cysteine Cathepsins in Parkinson's Disease Monocytes
Published 2024Better Parkinson’s disease (PD) biomarkers are needed to enable early detection, confirm diagnosis, monitor prognosis, or inform on stratification of PD patients into clinical trials. Leucine-rich repeat kinase 2 (LRRK2) ...USyd AccessThesis