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Pleiotropic roles, post-translational regulation and pharmacological targeting of NDRG1 in cancer
Published 2019-03-12
The metastasis suppressor, NDRG1, is a promising therapeutic target for cancer treatment. In past decade, much of the research has elucidated the anti-oncogenic molecular functions of NDRG1 in cancer cells. However, studies ...
USyd Access
Thesis
Detection of Alternative Lengthening of Telomeres in Telomerase-Positive Cancers
Published 2017-04-12
Immortalisation is a hallmark of cancer and requires activation of a telomere lengthening mechanism (TLM) to counteract natural telomere shortening. There are two TLMs: telomerase, reported in 85% of cancers, and Alternative ...
USyd Access
Thesis
Information Extraction from Radiology Reports for a Population Based Cancer Registry
Published 2013-03-31
In a noisy corpus such as in clinical data, the text usually contains a large number of misspell words, abbreviations and acronyms that can be an obstacle to high quality information extraction and classification. Furthermore, ...
USyd Access
Thesis
The LMO4-DEAF1 complex and its biological impacts
Published 2013-10-14
LIM domains are non-classical zinc fingers that bind other proteins. They have diverse cellular functions that range from regulating gene expression to maintaining the structural integrity of the cell. LIM domain-only ...
USyd Access
Thesis
A study of lymphoma in Bullmastiff dogs
Published 2019-06-14
Lymphoma is the most common cancer in Bullmastiffs and Bullmastiff is one of the breeds that are the most predisposed to lymphoma. The investigation of the population and genome started with the notice of high incidence ...
USyd Access
Thesis
LHRH-Receptor Mediated Targeting of Cancer Cells Using Curcumin Nano-micelle Formulation
Published 2018-09-22
Breast cancer is the most common malignancy and the second leading cause of cancer-related death among Australian women despite existing progress in the development of novel therapeutic strategies. Triple-negative breast ...
USyd Access
Thesis
A critical analysis of advance care planning in Australian cancer care
Published 2017-01-10
Over the past three decades, advance care planning (ACP) programs have been widely instituted and supported by legislation in many parts of the world. The objective of this thesis is explore both the concept and the practice ...
USyd Access
Thesis
Melanoma Patterns of Care Study New South Wales
Published 2016-03-01
The MPOC Study was a population-based study of the clinical management of melanoma patients in NSW. It included data on all melanoma diagnoses notified to the cancer registry during a 12-month period, and questionnaire ...
USyd Access
Thesis
Understanding the relationship between telomeres, telomerase, and DNA G-quadruplexes
Published 2017-09-29
Cancer cells elongate their telomeres - G-rich repetitive sequences found at the end of linear chromosomes, allowing limitless replicative potential in these cells. Approximately 85% of cancers use telomerase to extend ...
USyd Access
Thesis
EXPRESSION OF CYTOCHROME P450 2J2 AND CYCLOOXYGENASE-2 IN HUMAN BREAST CANCER CELLS AND STRATEGIES TO MINIMISE ANTI-TUMOUR DRUG RESISTANCE
Published 2015-12-15
Advanced cancers are often drug resistant and highly metastatic. Understanding the factors and mechanisms that drive metastasis and drug resistance could provide new targets for the development of innovative treatments. ...
USyd Access
Thesis