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Biomimetic 3D scaffold for cancer research
Published 2016-01-27
Cancer is a leading cause of death around the world in recent years. Tissue engineering and Materials Science are important tools in cancer research in the fields of basic pathology, drug discovery and radiation oncology. ...
USyd Access
PhD Doctorate
Pleiotropic roles, post-translational regulation and pharmacological targeting of NDRG1 in cancer
Published 2019-03-12
The metastasis suppressor, NDRG1, is a promising therapeutic target for cancer treatment. In past decade, much of the research has elucidated the anti-oncogenic molecular functions of NDRG1 in cancer cells. However, studies ...
USyd Access
PhD Doctorate
Cognitive function in cancer survivors following chemotherapy treatment
Published 2016-09-30
Cognitive symptoms are commonly reported by cancer patients. Research has shown that up to 70% of cancer patients experience symptoms of varying magnitude. Cognitive symptoms have consistently been shown to be associated ...
USyd Access
PhD Doctorate
Low risk ‘cancers’: how terminology impacts experiences of diagnosis, treatment preferences and psychological outcomes
Published 2018-09-03
A range of conditions with indolent to fast-growing lesions are labelled as ‘cancer’. Lesions with low malignant potential are common, and with the advent and use of increasingly sensitive technologies these indolent lesions ...
USyd Access
PhD Doctorate
The Design and Synthesis of Stabilised Cis- and Trans-Platinum (IV) Complexes for Targeted Drug Delivery
Published 2016-12-05
Platinum(IV) complexes are a promising class of pro-drugs which may bypass the problems associated with their platinum(II) counterparts, such as cisplatin and oxaliplatin. However, any pharmacokinetic advantages conferred ...
USyd Access
PhD Doctorate
The Role of RUNX Transcription Factors in Prostate Development and Tumorigenesis
Published 2016-12-22
Prostate cancer is the most prevalent malignant neoplasia affecting men over 65 years of age. While prostate carcinoma is considered mostly curable when confined to the prostatic capsule, more aggressive forms have a ...
USyd Access
PhD Doctorate
A critical analysis of advance care planning in Australian cancer care
Published 2017-01-10
Over the past three decades, advance care planning (ACP) programs have been widely instituted and supported by legislation in many parts of the world. The objective of this thesis is explore both the concept and the practice ...
USyd Access
PhD Doctorate
Evaluation of Sigma Receptor Drugs
Published 2015-12-30
Sigma receptors (σ-R) are unique mammalian proteins with two well-characterized subtypes (σ1 and σ2). They are widely distributed in the central nervous system (CNS) and periphery, and have been increasingly implicated in ...
USyd Access
PhD Doctorate
The role of vascular endothelial growth factor A in physiological and pathological angiogenesis
Published 2017-11-02
Vascular endothelial growth factor A (VEGF-A) is a major contributor to physiological and pathological angiogenesis in the body. VEGF-A exists as several isoforms varying significantly in their function and angiogenic ...
USyd Access
PhD Doctorate
Investigating the effectiveness of a psycho-educational intervention to reduce fear of cancer recurrence in people at high-risk of developing another primary melanoma
Published 2016-04-28
Melanoma is the fourth most common cancer in Australia and its incidence continue to increase. The diagnosis and treatment of melanoma can impact upon many aspects of an individual’s life, including psychological and ...
USyd Access
PhD Doctorate