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A study of lymphoma in Bullmastiff dogs
Published 2019-06-14
Lymphoma is the most common cancer in Bullmastiffs and Bullmastiff is one of the breeds that are the most predisposed to lymphoma. The investigation of the population and genome started with the notice of high incidence ...
USyd Access
Thesis
The LMO4-DEAF1 complex and its biological impacts
Published 2013-10-14
LIM domains are non-classical zinc fingers that bind other proteins. They have diverse cellular functions that range from regulating gene expression to maintaining the structural integrity of the cell. LIM domain-only ...
USyd Access
Thesis
LHRH-Receptor Mediated Targeting of Cancer Cells Using Curcumin Nano-micelle Formulation
Published 2018-09-22
Breast cancer is the most common malignancy and the second leading cause of cancer-related death among Australian women despite existing progress in the development of novel therapeutic strategies. Triple-negative breast ...
USyd Access
Thesis
Information Extraction from Radiology Reports for a Population Based Cancer Registry
Published 2013-03-31
In a noisy corpus such as in clinical data, the text usually contains a large number of misspell words, abbreviations and acronyms that can be an obstacle to high quality information extraction and classification. Furthermore, ...
USyd Access
Thesis
The glycoprotein Basigin in liver disease
Published 2016-06-30
Basigin (Bsg) is a membrane glycoprotein expressed by many different cell types. Bsg is instrumental in tissue development, extracellular matrix (ECM) remodelling, and has been implicated in numerous cancer types. The ...
USyd Access
Thesis
Detection of Alternative Lengthening of Telomeres in Telomerase-Positive Cancers
Published 2017-04-12
Immortalisation is a hallmark of cancer and requires activation of a telomere lengthening mechanism (TLM) to counteract natural telomere shortening. There are two TLMs: telomerase, reported in 85% of cancers, and Alternative ...
USyd Access
Thesis
Examining Instigators and Suppressors of Metastasis and Mitosis in Pancreatic Cancer
Published 2020
Cancer remains a leading health issue globally, whose burden of disease is predicted to rise. While recent advances have improved diagnostic and prognostic outcomes for many patients, there remains a desperate need for new ...
USyd Access
Thesis
Targeting non-oncogenic kinases DYRK1A and MK2 in glioblastoma
Published 2020
Glioblastoma represents the most common and aggressive primary brain tumour. Current treatment protocols however are mostly ineffective as all patients succumb to the disease within two years of diagnosis. Despite continued ...
USyd Access
Thesis
Extracellular Vesicles as Surrogates for Understanding and Monitoring Glioblastoma Progression
Published 2019-06-30
Glioblastoma (GBM; WHO grade IV glioma), is the most common and lethal adult primary brain tumour. Lack of sensitive monitoring methods contributes to poor patient outcomes. Extracellular vesicles (EVs) are stable nanoparticles ...
USyd Access
Thesis
An exploration of communication between emerging adults with cancer and nurses in an adult cancer care setting
Published 2019-01-01
Having a cancer diagnosis during early adulthood can bring significant challenges. It is important to provide supportive care with consideration of their developmental challenges. Nurses’ supportive communication plays a ...
USyd Access
Thesis