Research Publications and Outputs: Recent submissions
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Neuropeptide Y Knockout Mice Reveal a Central Role of NPY in the Coordination of Bone Mass to Body Weight
Published 2009-12-01Changes in whole body energy levels are closely linked to alterations in body weight and bone mass. Here, we show that hypothalamic signals contribute to the regulation of bone mass in a manner consistent with the central ...Open AccessArticle -
Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice
Published 2006-05-01Reduction in levels of sex hormones at menopause in women is associated with two common, major outcomes, the accumula- tion of white adipose tissue, and the progressive loss of bone because of excess osteoclastic bone ...Open AccessArticle -
Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets
Published 2012-04-01Food intake and body weight are controlled by a variety of central and peripheral factors, but the exact mechanisms behind these processes are still not fully understood. Here we show that that macrophage inhibitory ...Open AccessArticle -
TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator
Published 2013-02-01The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of ...Open AccessArticle -
NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice
Published 2010-06-01Open AccessArticle