• Cross-genotypic examination of hepatitis C virus polymerase inhibitors reveals a novel mechanism of action for thumb binders 

      Eltahla, Auda A; Tay, Enoch; Douglas, Mark; White, Peter A
      Published 2014-01-01
      Open Access
      Article
    • Interferon-λ rs12979860 genotype and liver fibrosis in viral and non-viral chronic liver disease 

      Eslam, Mohammed; Hashem, Ahmed M; Leung, Reynold; Romero-Gomez, Manuel; Berg, Thomas; Dore, Gregory; Chan, Henry L K; Irving, William; Sheridan, David; Abate, Maria; Mangia, Alessandra; Weltman, Martin; Bugianesi, Elisabetta; Spengler, Ulrich; Shaker, Olfat; Fischer, Janett; Mollison, Lindsay; Cheng, Wendy; Powell, Elizabeth; Nattermann, Jacob; Riordan, Stephen; McLeod, Duncan; Armstrong, Nicola J.; Douglas, Mark; Liddle, Christopher; Booth, David R.; George, Jacob; Ahlenstiel, Golo; International Hepatitis C Genetics Consortium (IHCGC)
      Published 2015-01-01
      Open Access
      Article
    • MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C 

      Thabet, Khaled; Asimakopoulos, Anastasia; Shojaei, Maryam; Romero-Gomez, Manuel; Mangia, Alessandra; Irving, William L.; Berg, Thomas; Dore, Gregory J.; Grønbæk, Henning; Sheridan, David; Abate, Maria; Bugianes, Elisabetta; Weltman, Martin; Mollison, Lindsay; Cheng, Wendy; Riordan, Stephen; Fischer, Janett; Spengler, Ulrich; Nattermann, Jacob; Wahid, Ahmed; Rojas, Angela; White, Rose; Douglas, Mark; McLeod, Duncan; Powell, Elizabeth; Liddle, Christopher; van der Poorten, David; George, Jacob; Eslam, Mohammed; International Liver Disease Genetics Consortium
      Published 2016-01-01
      Open Access
      Article
    • Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response 

      Read, Scott A; Tay, Enoch; Shahidi, Mahsa; O'Connor, Kate; Booth, David; George, Jacob; Douglas, Mark
      Published 2015-01-01
      Treatment of chronic hepatitis C virus (HCV) infection is evolving rapidly with the development of novel direct acting antivirals (DAAs), however viral clearance remains intimately linked to the hepatic innate immune system. ...
      Open Access
      Article
    • Hepatitis C Virus Induces the Cannabinoid Receptor 1 

      van der Poorten, David; Shahidi, Mahsa; Tay, Enoch; Sesha, Jayshree; Tran, Kayla; McLeod, Duncan; Milliken, J; Ho, Vicki; Hebbard, Lionel; Douglas, Mark; George, Jacob
      Published 2010-01-01
      Background: Activation of hepatic CB1 receptors (CB1) is associated with steatosis and fibrosis in experimental forms of liver disease. However, CB1 expression has not been assessed in patients with chronic hepatitis C ...
      Open Access
      Article