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Browsing Research Publications and Outputs by subject "029903"

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    • 4-Dimensional Cone Beam Computed Tomography-Measured Target Motion Underrepresents Actual Motion 

      Steiner, E; Shieh, CC; Caillet, V; Booth, J; Hardcastle, N; Briggs, A; Jayamanne, D; Haddad, C; Eade, T; Keall, P
      Published 2018-11-15
      PURPOSE: Four-dimensional cone beam computed tomography (4DCBCT) facilitates verification of lung tumor motion before each treatment fraction and enables accurate patient setup in lung stereotactic ablative body radiation ...
      Open Access
      Article
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    • Audiovisual Biofeedback Improves Cine-Magnetic Resonance Imaging Measured Lung Tumor Motion Consistency. 

      Lee, D; Greer, PB; Ludbrook, J; Arm, J; Hunter, P; Pollock, S; Makhija, K; O'Brien, RT; Kim, T; Keall, P
      Published 2016-03-01
      PURPOSE: To assess the impact of an audiovisual (AV) biofeedback on intra- and interfraction tumor motion for lung cancer patients. METHODS AND MATERIALS: Lung tumor motion was investigated in 9 lung cancer patients who ...
      Open Access
      Article
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    • The Australian magnetic resonance imaging-linac program. 

      Keall, P; Barton, M; Crozier, S
      Published 2014-07-01
      The Australian magnetic resonance imaging (MRI)-Linac program is a $16-million government-funded project to advance the science and clinical practice of exquisite real-time anatomical and physiological adaptive cancer ...
      Open Access
      Article
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    • Both four-dimensional computed tomography and four-dimensional cone beam computed tomography under-predict lung target motion during radiotherapy. 

      Steiner, E; Shieh, CC; Caillet, V; Booth, J; O'Brien, R; Briggs, A; Hardcastle, N; Jayamanne, D; Szmura, K; Eade, T; Keall, P
      Published 2019-06-01
      BACKGROUND AND PURPOSE: To test the hypothesis that 4DCT and 4DCBCT-measured target motion ranges predict target motion ranges during lung cancer SABR. MATERIALS AND METHODS: Ten lung SABR patients were implanted with ...
      Open Access
      Article
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    • Breathing guidance in radiation oncology and radiology: A systematic review of patient and healthy volunteer studies. 

      Pollock, S; Keall, P
      Published 2015-09-01
      PURPOSE: The advent of image-guided radiation therapy has led to dramatic improvements in the accuracy of treatment delivery in radiotherapy. Such advancements have highlighted the deleterious impact tumor motion can ...
      Open Access
      Article
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    • Changes in Regional Ventilation During Treatment and Dosimetric Advantages of CT Ventilation Image Guided Radiation Therapy for Locally Advanced Lung Cancer 

      Yamamoto, T; Kabus, S; Bal, M; Bzdusek, K; Keall, P; Wright, C; Benedict, SH; Daly, ME
      Published 2018-11-15
      PURPOSE: Lung functional image guided radiation therapy (RT) that avoids irradiating highly functional regions has potential to reduce pulmonary toxicity following RT. Tumor regression during RT is common, leading to ...
      Open Access
      Article
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    • Determining appropriate imaging parameters for kilovoltage intrafraction monitoring: an experimental phantom study. 

      Wallace, D; Ng, JA; Keall, P; O'Brien, RT; Poulsen, PR; Juneja, P; Booth, JT
      Published 2015-06-01
      Kilovoltage intrafraction monitoring (KIM) utilises the kV imager during treatment for real-time tracking of prostate fiducial markers. However, its effectiveness relies on sufficient image quality for the fiducial tracking ...
      Open Access
      Article
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    • Development and commissioning of a full-size prototype fixed-beam radiotherapy system with horizontal patient rotation. 

      Liu, PZY; O'Brien, R; Heng, SM; Newall, M; Downes, S; Shieh, CC; Corde, S; Jackson, M; Keall, P
      Published 2019-03-01
      PURPOSE: Compared to conventional linacs with rotating gantries, a fixed-beam radiotherapy system could be smaller, more robust and more cost-effective. In this work, we developed and commissioned a prototype x-ray ...
      Open Access
      Article
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    • Development and testing of a database of NIH research funding of AAPM members: A report from the AAPM Working Group for the Development of a Research Database (WGDRD). 

      Whelan, B; Moros, EG; Fahrig, R; Deye, J; Yi, T; Woodward, N; Keall, P; Siewerdsen, JH
      Published 2017-04-01
      PURPOSE: To produce and maintain a database of National Institutes of Health (NIH) funding of the American Association of Physicists in Medicine (AAPM) members, to perform a top-level analysis of these data, and to make ...
      Open Access
      Article
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    • Dose enhancement in radiotherapy of small lung tumors using inline magnetic fields: A Monte Carlo based planning study 

      Oborn, B; Ge, Y; Hardcastle, N; Metcalfe, P; Keall, P
      Published 2016-01-01
      PURPOSE: To report on significant dose enhancement effects caused by magnetic fields aligned parallel to 6 MV photon beam radiotherapy of small lung tumors. Findings are applicable to future inline MRI-guided radiotherapy ...
      Open Access
      Article
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    • Dynamic keyhole: a novel method to improve MR images in the presence of respiratory motion for real-time MRI 

      Lee, D; Pollock, S; Whelan, B; Keall, P; Kim, T
      Published 2014-07-01
      PURPOSE: In this work, the authors present a novel magnetic resonance imaging reconstruction method to improve the quality of MR images in the presence of respiratory motion for real-time thoracic image-guided radiotherapy. ...
      Open Access
      Article
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    • Electromagnetic detection and real-time DMLC adaptation to target rotation during radiotherapy. 

      Wu, J; Ruan, D; Cho, B; Sawant, A; Petersen, J; Newell, LJ; Cattell, H; Keall, P
      Published 2012-03-01
      PURPOSE: Intrafraction rotation of more than 45° and 25° has been observed for lung and prostate tumors, respectively. Such rotation is not routinely adapted to during current radiotherapy, which may compromise tumor dose ...
      Open Access
      Article
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    • Electron contamination modeling and reduction in a 1 T open bore inline MRI-linac system 

      Oborn, B; Kolling, S; Metcalfe, P; Crozier, S; Litzenberg, D; Keall, P
      Published 2014-05-01
      PURPOSE: A potential side effect of inline MRI-linac systems is electron contamination focusing causing a high skin dose. In this work, the authors reexamine this prediction for an open bore 1 T MRI system being constructed ...
      Open Access
      Article
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    • Electron contamination modeling and skin dose in 6 MV longitudinal field MRIgRT: Impact of the MRI and MRI fringe field. 

      Oborn, BM; Metcalfe, PE; Butson, MJ; Rosenfeld, AB; Keall, P
      Published 2012-02-01
      Purpose: In recent times, longitudinal field MRI‐linac systems have been proposed for 6 MV MRI‐guided radiotherapy (MRIgRT). The magnetic field is parallel with the beam axis and so will alter the transport properties of ...
      Open Access
      Article
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    • Estimating lung ventilation directly from 4D CT Hounsfield unit values 

      Kipritidis, J; Hofman, M; Siva, S; Callahan, J; Le Roux, P; Woodruff, H; Counter, W; Keall, P
      Published 2016-01-01
      PURPOSE: Computed tomography ventilation imaging (CTVI) aims to visualize air-volume changes in the lung by quantifying respiratory motion in 4DCT using deformable image registration (DIR). A problem is that DIR-based ...
      Open Access
      Article
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    • Fast motion-including dose error reconstruction for VMAT with and without MLC tracking 

      Rakvilde, T; Keall, P; Grau, C; Høyer, M; Poulsen, PR
      Published 2014-12-01
      Multileaf collimator (MLC) tracking is a promising and clinically emerging treatment modality for radiotherapy of mobile tumours. Still, new quality assurance (QA) methods are warranted to safely introduce MLC tracking in ...
      Open Access
      Article
      View
    • A Feasibility Study of Single-inhalation, Single-energy Xenon-enhanced CT for High-resolution Imaging of Regional Lung Ventilation in Humans. 

      Pinkham, DW; Negahdar, M; Yamamoto, T; Mittra, E; Diehn, M; Nair, VS; Keall, P; Maxim, PG; Loo, BW Jr
      Published 2019-01-01
      RATIONALE AND OBJECTIVES: The objective of this study was to assess the feasibility of single-inhalation xenon-enhanced computed tomography (XeCT) to provide clinically practical, high-resolution pulmonary ventilation ...
      Open Access
      Article
      View
    • The first clinical implementation of a real-time six degree of freedom target tracking system during radiation therapy based on Kilovoltage Intrafraction Monitoring (KIM). 

      Nguyen, DT; O'Brien, R; Kim, JH; Huang, CY; Wilton, L; Greer, P; Legge, K; Booth, JT; Poulsen, PR; Martin, J; Keall, P
      Published 2017-04-01
      PURPOSE: We present the first clinical implementation of a real-time six-degree of freedom (6DoF) Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during ...
      Open Access
      Article
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    • The first clinical treatment with kilovoltage intrafraction monitoring (KIM): A real-time image guidance method 

      Keall, P; Ng, J; O'Brien, R; Colvill, E; Huang, C-Y; Poulsen, P; Fledelius, W; Juneja, P; Simpson, E; Bell, L; Alfieri, F; Eade, T; Kneebone, A; Booth, J
      Published 2015-01-01
      PURPOSE: Kilovoltage intrafraction monitoring (KIM) is a real-time image guidance method that uses widely available radiotherapy technology, i.e., a gantry-mounted x-ray imager. The authors report on the geometric and ...
      Open Access
      Article
      View
    • The First Implementation of Respiratory Triggered 4DCBCT on a Linear Accelerator 

      O'Brien, R; Cooper, B; Shieh, C-C; Stankovic, U; Keall, P; Sonke, J-J
      Published 2016-05-01
      Four Dimensional Cone Beam Computed Tomography (4DCBCT) is an image guidance strategy used for patient positioning in radiotherapy. In conventional implementations of 4DCBCT, a constant gantry speed and a constant projection ...
      Open Access
      Article
      View
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