Research Publications and Outputs: Recent submissions
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Cisplatin drug delivery using gold-coated iron oxide nanoparticles for enhanced tumour targeting with external magnetic fields
Published 2012-05-30The platinum-based chemotherapeutic drug cisplatin is highly effective in the treatment of solid tumours, but its use is restricted by poor bioavailability, severe dose-limiting side effects and rapid development of drug ...Open AccessArticle -
Evaluation of anionic half generation 3.5–6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin
Published 2011-05-27Aquated cisplatin was added to half-generation PAMAM dendrimers and the resultant complexes were purified by centrifuge. The drug–dendrimer complexes were then characterised by 1-D and diffusion 1H NMR and ICP-AES. The ...Open AccessArticle -
Folding of dinuclear platinum anticancer complexes within the cavity of para-sulphonatocalix[4]arene
Published 2012-05-03The binding of three dinuclear platinum complexes, where the bridging ligand of the complexes is N,N0- (alkane-1,n-diyl)diisonicotinamide (n = 4, 6 or 8 for butane, hexane and octane, respectively) to the macrocycle ...Open AccessArticle -
The status of platinum anticancer drugs in the clinic and in clinical trials
Published 2010-06-30Since its approval in 1979 cisplatin has become an important component in chemotherapy regimes for the treatment of ovarian, testicular, lung and bladder cancers, as well as lymphomas, myelomas and melanoma. Unfortunately ...Open AccessArticle -
Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect
Published 2012-04-18The cucurbit[n]uril (CB[n]) family of macrocycles has been shown to have potential in drug delivery where they are able to provide physical and chemical stability to drugs, improve drug solubility, control drug release and ...Open AccessArticle