Sydney Pharmacy School: Recent submissions

    • Production of Inhalable Bacteriophage Dry Powders 

      Leung, Sharon SY; Parumasivam, Thaigarajan; Carter, Elizabeth A; Carrigy, Nicholas B; Vehring, Reinhard; Finlay, Warren H; Morales, Sandra; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim
      Published 2017-04-28
      Phage therapy is a possible alternative to conventional antibiotics to treat pulmonary infections caused by multidrug resistance (MDR) bacterial strains [1-4], due to its high specificity, low toxicity, capability of ...
      Open Access
      Conference paper
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    • Effects of storage conditions on the stability of spray dried, inhalable bacteriophage powders 

      Leung, Sharon SY; Parumasivam, Thaigarajan; Gao, Fiona G; Carrigy, Nicholas B; Vehring, Reinhard; Finlay, Warren H; Morales, Sandra; Britton, Warwick J; Kutter, Elizabeth; Chan, Hak-Kim
      Published 2017-04-15
      This study aimed to develop inhalable powders containing phages active against antibiotic-resistant Pseudomonas aeruginosa for pulmonary delivery. A Pseudomonas phage, PEV2, was spray dried into powder matrices comprising ...
      Open Access
      Article
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    • Microfluidic-assisted bacteriophage encapsulation into liposomes 

      Leung, Sharon SY; Morales, Sandra; Britton, Warwick; Kutter, Elizabeth; Chan, Hak-Kim
      Published 2018-07-10
      Microfluidics has recently emerged as a new method of manufacturing liposomes, which allows reproducible mixing in miliseconds on the nanoliter scale. Here we investigated the feasibility of a microfluidic flow focusing ...
      Open Access
      Article
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    • Nebulisation effects on structural stability of bacteriophage PEV44 

      Astudillo, Ariel; Leung, Sharon Shui Yee; Kutter, Elizabeth; Morales, Sandra; Britton, Warwick J; Chan, Hak-Kim
      Published 2017-08-11
      Nebulization being used for inhaled phage therapy can cause phage titer losses which may be the result of mechanical damage to the phages. This study aimed to determine effects of nebulization on the structural stability ...
      Open Access
      Conference paper
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    • Nebulization effects on structural stability of bacteriophage PEV 44 

      Astudillo, Ariel; Leung, Sharon Shui Yee; Kutter, Elizabeth; Morales, Sandra; Chan, Hak-Kim
      Published 2018-01-17
      Reduced infectivity of phage due to the nebulization process has been reported previously, but no visual evidence on structural change upon nebulization has been established, or whether these structural changes can be ...
      Open Access
      Article
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