Browsing Medicine by publication year
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Single Nucleotide Differences (SNDs) in the dbSNP database may lead to errors in genotyping and haplotyping studies
Published 2009-01-01The creation of single-nucleotide polymorphism (SNP) databases (such as NCBI dbSNP) has facilitated scientific research in many fields. SNP discovery and detection has improved to the extent that there are over 17 million ...Open AccessDataset -
Harvest: an open-source tool for the validation and improvement of peptide identification metrics and fragmentation exploration
Published 2010-01-01Background// Protein identification using mass spectrometry is an important tool in many areas of the life sciences, and in proteomics research in particular. Increasing the number of proteins correctly identified is ...Open AccessSoftware -
Asking young Aboriginal people who use illicit drugs about their healthcare preferences using audio-computer-assisted self-interviewing
Published 2019Introduction and Aims Substance use significantly contributes to increasing the disease burden experienced by young Aboriginal and Torres Strait Islander (Aboriginal) Australians. Little is known about the primary ...Open AccessArticle -
Real-time direct diaphragm tracking using kV imaging on a standard linear accelerator.
Published 2019-01-01Purpose: As the predominant driver of respiratory motion, the diaphragm represents a key surrogate for motion management during the irradiation of thoracic cancers. Existing approaches to diaphragm tracking often produce ...Open AccessArticle -
Technical Note: The first live treatment on a 1.0 Tesla inline MRI-linac.
Published 2019-01-01Purpose: This work describes the first live imaging and radiation delivery performed on a prototype 1.0 T inline MRI-Linac system in a rat brain tumor model, which was conducted on 29 January 2019. Methods: A human scale ...Open AccessArticle -
Dual cardiac and respiratory gated thoracic imaging via adaptive gantry velocity and projection rate modulation on a linear accelerator: A Proof-of-Concept Simulation Study.
Published 2019-01-01Purpose: Cardiac motion is typically not accounted for during pretreatment imaging for central lung and mediastinal tumors. However, cardiac induced tumor motion averages 5.8 mm for esophageal tumors and 3-5 mm for some ...Open AccessArticle -
See, Think, and Act: Real-Time Adaptive Radiotherapy.
Published 2019-01-01The world is embracing the information age, with real-time data at hand to assist with many decisions. Similarly, in cancer radiotherapy we are inexorably moving toward using information in a smarter and faster fashion, ...Open AccessArticle -
Dosimetric impact of intrafraction rotations in stereotactic prostate radiotherapy: A subset analysis of the TROG 15.01 SPARK trial.
Published 2019-01-01Background and purpose: Accurate delivery of radiotherapy is critical to achieve optimal treatment outcomes. Interfraction translational IGRT is now standard, and intrafraction motion management is becoming accessible. ...Open AccessArticle -
Time-resolved Volumetric MRI in MRI-guided Radiotherapy: An in Silico Comparative Analysis
Published 2019-01-01MRI-treatment units enable 2D cine-MRI centred in the tumour for motion detection in radiotherapy, but they lack 3D information due to spatio-temporal limits. To derive time-resolved 3D information, different approaches ...Open AccessArticle -
The Accuracy and Precision of the KIM Motion Monitoring System Used in the Multi-Institutional TROG 15.01 Stereotactic Prostate Ablative Radiotherapy With KIM (SPARK) Trial
Published 2019-01-01Purpose: Kilovoltage intrafraction monitoring (KIM) allows for real-time image guidance for tracking tumor motion in six-degrees-of-freedom (6DoF) on a standard linear accelerator. This study assessed the geometric accuracy ...Open AccessArticle -
Technical Note: Experimental Characterization of the Dose Deposition in Parallel MRI-linacs at Various Magnetic Field Strengths
Published 2019-01-01Purpose: Dose deposition measurements for parallel MRI-linacs have previously only shown comparisons between 0 T and a single available magnetic field. The Australian MRI-Linac consists of a magnet coupled with a dual ...Open AccessArticle -
Imaging of regional ventilation: Is CT ventilation imaging the answer? A systematic review of the validation data.
Published 2019-01-01Computed Tomography Ventilation Imaging (CTVI) is an experimental imaging modality that derives regional lung function information from non-contrast respiratory-correlated CT datasets. Despite CTVI being extensively studied ...Open AccessArticle -
Anatomical Deformation Due to Horizontal Rotation: Towards Gantry-Free Radiation Therapy
Published 2019-01-01Gantry-free radiation therapy systems may be simpler and more cost effective, particularly for MRI-guided photon or hadron therapy. This study aims to understand and quantify anatomical deformations caused by horizontal ...Open AccessArticle -
FLASH radiotherapy: Newsflash or flash in the pan?
Published 2019-01-01No abstract. A point / counterpoint article on the merits of ultra-high dose rate radiation therapy.Open AccessArticle -
SPARE: Sparse-view reconstruction challenge for 4D cone-beam CT from a 1-min scan.
Published 2019-01-01Purpose: Currently, four-dimensional (4D) cone-beam computed tomography (CBCT) requires a 3-4 min full-fan scan to ensure usable image quality. Recent advancements in sparse-view 4D-CBCT reconstruction have opened the ...Open AccessArticle -
Simulated multileaf collimator tracking for stereotactic liver radiotherapy guided by kilovoltage intrafraction monitoring: Dosimetric gain and target overdose trends
Published 2020Purpose: To investigate the potential benefit of multileaf collimator (MLC) tracking guided by kilovoltage intrafraction monitoring (KIM) during stereotactic body radiotherapy (SBRT) in the liver, and to understand trends ...Open AccessArticle -
Optimising lung imaging for cancer radiation therapy
Published 2020Effective radiotherapy is dependent on being able to (i) visualise the tumour clearly, and (ii) deliver the correct dose to the cancerous tissue, whilst sparing the healthy tissue as much as possible. In the presence of ...Open AccessArticle -
'That thing in his head': Aboriginal and non-Aboriginal Australian caregiver responses to neurodevelopmental disability diagnoses
Published 2020Little is known about the significance of cultural differences to how caregivers receive a diagnosis of neurodevelopmental disability. As part of a Fetal Alcohol Spectrum Disorder prevalence study among sentenced, detained ...Open AccessArticle -
Real-Time Image Guided Ablative Prostate Cancer Radiation Therapy: Results From the TROG 15.01 SPARK Trial
Published 2020Purpose: Kilovoltage intrafraction monitoring (KIM) is a novel software platform implemented on standard radiation therapy systems and enabling real-time image guided radiation therapy (IGRT). In a multi-institutional ...Open AccessArticle -
Reducing 4D CT imaging artifacts at the source: first experimental results from the respiratory adaptive computed tomography (REACT) system
Published 2020Breathing variations during 4D CT imaging often manifest as geometric irregularities known as respiratory-induced image artifacts and ultimately effect radiotherapy treatment efficacy. To reduce such image artifacts we ...Open AccessArticle